Circadian disruption, Per3, and human cytokine secretion

Jaclyn Guess; James B. Burch; Kisito Ogoussan; Cheryl A. Armstead; Hongmei Zhang; Sara Wagner; James R. Hebert; Patricia Wood; Shawn D. Youngstedt; Lorne J. Hofseth; Udai P. Singh; Dawen Xie; William L.M. Hrushesky

doi:10.1177/1534735409352029

Circadian disruption, Per3, and human cytokine secretion

Jaclyn Guess, James B. Burch, Kisito Ogoussan, Cheryl A. Armstead, Hongmei Zhang, Sara Wagner, James R. Hebert, Patricia Wood, Shawn D. Youngstedt, Lorne J. Hofseth, Udai P. Singh, Dawen Xie, William L.M. Hrushesky

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.

Original language	English (US)
Pages (from-to)	329-336
Number of pages	8
Journal	Integrative cancer therapies
Volume	8
Issue number	4
DOIs	https://doi.org/10.1177/1534735409352029
State	Published - 2009
Externally published	Yes

Keywords

Circadian rhythm
Clock gene
Cytokine
Inflammation

ASJC Scopus subject areas

Oncology
Complementary and alternative medicine

Access to Document

10.1177/1534735409352029

Cite this

@article{e80ad2fda4b44a058ca8af44b4944fb9,

title = "Circadian disruption, Per3, and human cytokine secretion",

abstract = "Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.",

keywords = "Circadian rhythm, Clock gene, Cytokine, Inflammation",

author = "Jaclyn Guess and Burch, {James B.} and Kisito Ogoussan and Armstead, {Cheryl A.} and Hongmei Zhang and Sara Wagner and Hebert, {James R.} and Patricia Wood and Youngstedt, {Shawn D.} and Hofseth, {Lorne J.} and Singh, {Udai P.} and Dawen Xie and Hrushesky, {William L.M.}",

year = "2009",

doi = "10.1177/1534735409352029",

language = "English (US)",

volume = "8",

pages = "329--336",

journal = "Integrative cancer therapies",

issn = "1534-7354",

publisher = "SAGE Publications Inc.",

number = "4",

}

TY - JOUR

T1 - Circadian disruption, Per3, and human cytokine secretion

AU - Guess, Jaclyn

AU - Burch, James B.

AU - Ogoussan, Kisito

AU - Armstead, Cheryl A.

AU - Zhang, Hongmei

AU - Wagner, Sara

AU - Hebert, James R.

AU - Wood, Patricia

AU - Youngstedt, Shawn D.

AU - Hofseth, Lorne J.

AU - Singh, Udai P.

AU - Xie, Dawen

AU - Hrushesky, William L.M.

PY - 2009

Y1 - 2009

N2 - Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.

AB - Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.

KW - Circadian rhythm

KW - Clock gene

KW - Cytokine

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=77949358945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949358945&partnerID=8YFLogxK

U2 - 10.1177/1534735409352029

DO - 10.1177/1534735409352029

M3 - Article

C2 - 19926609

AN - SCOPUS:77949358945

SN - 1534-7354

VL - 8

SP - 329

EP - 336

JO - Integrative cancer therapies

JF - Integrative cancer therapies

IS - 4

ER -

Circadian disruption, Per3, and human cytokine secretion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this