Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Zongxing Wang, Hung Jen Wu, Daniel Fine, Jeffrey Schmulen, Ye Hu, Biana Godin, John X.J. Zhang, Xuewu Liu

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

We fabricated a microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure. We demonstrated that the prototype device can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris. Trapped lipid vesicles can be recovered intact by dissolving the porous nanowires in PBS buffer.

Original languageEnglish (US)
Pages (from-to)2879-2882
Number of pages4
JournalLab on a Chip
Volume13
Issue number15
DOIs
StatePublished - Aug 7 2013
Externally publishedYes

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Nanowires
Microfluidics
Lab-On-A-Chip Devices
Lipids
Exosomes
Porous silicon
Silicon
Debris
Buffers
Proteins
Equipment and Supplies

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Wang, Z., Wu, H. J., Fine, D., Schmulen, J., Hu, Y., Godin, B., ... Liu, X. (2013). Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab on a Chip, 13(15), 2879-2882. https://doi.org/10.1039/c3lc41343h

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. / Wang, Zongxing; Wu, Hung Jen; Fine, Daniel; Schmulen, Jeffrey; Hu, Ye; Godin, Biana; Zhang, John X.J.; Liu, Xuewu.

In: Lab on a Chip, Vol. 13, No. 15, 07.08.2013, p. 2879-2882.

Research output: Contribution to journalArticle

Wang, Z, Wu, HJ, Fine, D, Schmulen, J, Hu, Y, Godin, B, Zhang, JXJ & Liu, X 2013, 'Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles', Lab on a Chip, vol. 13, no. 15, pp. 2879-2882. https://doi.org/10.1039/c3lc41343h
Wang, Zongxing ; Wu, Hung Jen ; Fine, Daniel ; Schmulen, Jeffrey ; Hu, Ye ; Godin, Biana ; Zhang, John X.J. ; Liu, Xuewu. / Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. In: Lab on a Chip. 2013 ; Vol. 13, No. 15. pp. 2879-2882.
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