Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Jing Zhen Deng, A. Sun Di-An, Shelley R. Starck, Sidney M. Hecht, Ronald L. Cerny, John R. Engen

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 μM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl /n-methylhydroquinone occurring in a higher terrestrial plant.

Original languageEnglish (US)
Pages (from-to)1147-1149
Number of pages3
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number9
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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