TY - JOUR
T1 - Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore
AU - Kleen, Jonathan K.
AU - Sitomer, Matthew T.
AU - Killeen, Peter R.
AU - Conrad, Cheryl
PY - 2006/8
Y1 - 2006/8
N2 - This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans.
AB - This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans.
KW - Hippocampus
KW - Metabolism
KW - Motivation spatial memory
KW - Operant conditioning
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=33746224915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746224915&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.120.4.842
DO - 10.1037/0735-7044.120.4.842
M3 - Article
C2 - 16893290
AN - SCOPUS:33746224915
SN - 0735-7044
VL - 120
SP - 842
EP - 851
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 4
ER -