Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

K. J. McLaughlin, S. E. Baran, R. L. Wright, Cheryl Conrad

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Emerging data report sex differences in how the brain responds to chronic stress. Here, we investigated the effects of chronic restraint stress (6 h/day/21 days) on hippocampal morphology and function in ovariectomized female rats. Chronic restraint stress caused CA3 apical dendritic retraction in short- and long-shafted neurons, while it reduced basal dendritic arbors in long-shafted neurons only. Chronic restraint did not affect CA1 dendritic arborization, although it increased the proportion of CA1 spine heads compared with controls. Both stressed and control animals performed well on the Y-maze, a spatial memory task. However, chronic stress enhanced Y-maze performance compared with controls, which may reflect facilitated spatial memory or reduced habituation. Y-maze performance correlated with CA1 spine head proportion. This relationship suggests that spatial ability in females may be more tightly coupled with CA1 morphology, which may override the influence of CA3 dendritic retraction. Thus, this research provides additional evidence that CA3 morphology does not always parallel spatial memory.

Original languageEnglish (US)
Pages (from-to)1045-1054
Number of pages10
JournalNeuroscience
Volume135
Issue number4
DOIs
StatePublished - Oct 14 2005

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Keywords

  • Chronic stress
  • Dendritic spines
  • Females
  • Hippocampus
  • Spatial recognition memory

ASJC Scopus subject areas

  • Neuroscience(all)

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