Cholangiocarcinoma in primary sclerosing cholangitis

Ghulam Abbas, Keith D. Lindor

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Introduction: Cholangiocarcinoma (CCA) is an aggressive and nearly always fatal tumor of the biliary tract. Purpose: This review explores risk factors, epidemiology, current diagnostic approaches, and treatment of CCA arising in patients with primary sclerosing cholangitis (PSC). Methods: We review latest recommendations about screening strategies to enable the early detection of CCA in PSC, using CA 19-9 and ultrasound imaging, as well as fluorescent in situ hybridization techniques to enhance the accuracy of biliary cytology. We also review the emerging role of liver transplantation.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalJournal of Gastrointestinal Cancer
Volume40
Issue number1-2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • Cholangiocarcinoma
  • Diagnosis
  • Epidemiology
  • Primary sclerosing cholangitis
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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