Chlamydia trachomatis pneumonia induces in vivo production of interleukin- 1 and -6

D. M. Magee, J. G. Smith, C. A. Bleicker, C. J. Carter, L. F. Bonewald, J. Schachter, D. M. Williams

Research output: Contribution to journalComment/debatepeer-review

34 Scopus citations

Abstract

Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in murine lungs. mRNA and bioactivity for IL-1α, IL-1β, and IL-6 increased after Chlamydia infection. These cytokines may be important in regulating host defenses against C. trachomatis.

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalInfection and immunity
Volume60
Issue number3
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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