Chimpanzee genomic diversity reveals ancient admixture with bonobos

Marc De Manuel; Martin Kuhlwilm; Peter Frandsen; Vitor C. Sousa; Tariq Desai; Javier Prado-Martinez; Jessica Hernandez-Rodriguez; Isabelle Dupanloup; Oscar Lao; Pille Hallast; Joshua M. Schmidt; José María Heredia-Genestar; Andrea Benazzo; Guido Barbujani; Benjamin M. Peter; Lukas F K Kuderna; Ferran Casals; Samuel Angedakin; Mimi Arandjelovic; Christophe Boesch; Hjalmar Kühl; Linda Vigilant; Kevin Langergraber; John Novembre; Marta Gut; Ivo Gut; Arcadi Navarro; Frands Carlsen; Aida M. Andrés; Hans R. Siegismund; Aylwyn Scally; Laurent Excoffier; Chris Tyler-Smith; Sergi Castellano; Yali Xue; Christina Hvilsom; Tomas Marques-Bonet

doi:10.1126/science.aag2602

Chimpanzee genomic diversity reveals ancient admixture with bonobos

Marc De Manuel, Martin Kuhlwilm, Peter Frandsen, Vitor C. Sousa, Tariq Desai, Javier Prado-Martinez, Jessica Hernandez-Rodriguez, Isabelle Dupanloup, Oscar Lao, Pille Hallast, Joshua M. Schmidt, José María Heredia-Genestar, Andrea Benazzo, Guido Barbujani, Benjamin M. Peter, Lukas F K Kuderna, Ferran Casals, Samuel Angedakin, Mimi Arandjelovic, Christophe BoeschHjalmar Kühl, Linda Vigilant, Kevin Langergraber, John Novembre, Marta Gut, Ivo Gut, Arcadi Navarro, Frands Carlsen, Aida M. Andrés, Hans R. Siegismund, Aylwyn Scally, Laurent Excoffier, Chris Tyler-Smith, Sergi Castellano, Yali Xue, Christina Hvilsom, Tomas Marques-Bonet

Human Evolution and Social Change, School of (SHESC)

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa.We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.

Original language	English (US)
Pages (from-to)	477-481
Number of pages	5
Journal	Science
Volume	354
Issue number	6311
DOIs	https://doi.org/10.1126/science.aag2602
State	Published - Oct 28 2016

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De Manuel, M., Kuhlwilm, M., Frandsen, P., Sousa, V. C., Desai, T., Prado-Martinez, J., Hernandez-Rodriguez, J., Dupanloup, I., Lao, O., Hallast, P., Schmidt, J. M., Heredia-Genestar, J. M., Benazzo, A., Barbujani, G., Peter, B. M., Kuderna, L. F. K., Casals, F., Angedakin, S., Arandjelovic, M., ... Marques-Bonet, T. (2016). Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science, 354(6311), 477-481. https://doi.org/10.1126/science.aag2602

De Manuel, M, Kuhlwilm, M, Frandsen, P, Sousa, VC, Desai, T, Prado-Martinez, J, Hernandez-Rodriguez, J, Dupanloup, I, Lao, O, Hallast, P, Schmidt, JM, Heredia-Genestar, JM, Benazzo, A, Barbujani, G, Peter, BM, Kuderna, LFK, Casals, F, Angedakin, S, Arandjelovic, M, Boesch, C, Kühl, H, Vigilant, L, Langergraber, K, Novembre, J, Gut, M, Gut, I, Navarro, A, Carlsen, F, Andrés, AM, Siegismund, HR, Scally, A, Excoffier, L, Tyler-Smith, C, Castellano, S, Xue, Y, Hvilsom, C & Marques-Bonet, T 2016, 'Chimpanzee genomic diversity reveals ancient admixture with bonobos', Science, vol. 354, no. 6311, pp. 477-481. https://doi.org/10.1126/science.aag2602

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abstract = "Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa.We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.",

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AU - Carlsen, Frands

AU - Andrés, Aida M.

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AU - Excoffier, Laurent

AU - Tyler-Smith, Chris

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Chimpanzee genomic diversity reveals ancient admixture with bonobos

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