Chimpanzee genomic diversity reveals ancient admixture with bonobos

Marc De Manuel, Martin Kuhlwilm, Peter Frandsen, Vitor C. Sousa, Tariq Desai, Javier Prado-Martinez, Jessica Hernandez-Rodriguez, Isabelle Dupanloup, Oscar Lao, Pille Hallast, Joshua M. Schmidt, José María Heredia-Genestar, Andrea Benazzo, Guido Barbujani, Benjamin M. Peter, Lukas F K Kuderna, Ferran Casals, Samuel Angedakin, Mimi Arandjelovic, Christophe BoeschHjalmar Kühl, Linda Vigilant, Kevin Langergraber, John Novembre, Marta Gut, Ivo Gut, Arcadi Navarro, Frands Carlsen, Aida M. Andrés, Hans R. Siegismund, Aylwyn Scally, Laurent Excoffier, Chris Tyler-Smith, Sergi Castellano, Yali Xue, Christina Hvilsom, Tomas Marques-Bonet

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa.We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalScience
Volume354
Issue number6311
DOIs
StatePublished - Oct 28 2016

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Pan paniscus
Pan troglodytes
Genome
Cameroon
Gene Flow
Hominidae
Nigeria
Demography

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

De Manuel, M., Kuhlwilm, M., Frandsen, P., Sousa, V. C., Desai, T., Prado-Martinez, J., ... Marques-Bonet, T. (2016). Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science, 354(6311), 477-481. https://doi.org/10.1126/science.aag2602

Chimpanzee genomic diversity reveals ancient admixture with bonobos. / De Manuel, Marc; Kuhlwilm, Martin; Frandsen, Peter; Sousa, Vitor C.; Desai, Tariq; Prado-Martinez, Javier; Hernandez-Rodriguez, Jessica; Dupanloup, Isabelle; Lao, Oscar; Hallast, Pille; Schmidt, Joshua M.; Heredia-Genestar, José María; Benazzo, Andrea; Barbujani, Guido; Peter, Benjamin M.; Kuderna, Lukas F K; Casals, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe; Kühl, Hjalmar; Vigilant, Linda; Langergraber, Kevin; Novembre, John; Gut, Marta; Gut, Ivo; Navarro, Arcadi; Carlsen, Frands; Andrés, Aida M.; Siegismund, Hans R.; Scally, Aylwyn; Excoffier, Laurent; Tyler-Smith, Chris; Castellano, Sergi; Xue, Yali; Hvilsom, Christina; Marques-Bonet, Tomas.

In: Science, Vol. 354, No. 6311, 28.10.2016, p. 477-481.

Research output: Contribution to journalArticle

De Manuel, M, Kuhlwilm, M, Frandsen, P, Sousa, VC, Desai, T, Prado-Martinez, J, Hernandez-Rodriguez, J, Dupanloup, I, Lao, O, Hallast, P, Schmidt, JM, Heredia-Genestar, JM, Benazzo, A, Barbujani, G, Peter, BM, Kuderna, LFK, Casals, F, Angedakin, S, Arandjelovic, M, Boesch, C, Kühl, H, Vigilant, L, Langergraber, K, Novembre, J, Gut, M, Gut, I, Navarro, A, Carlsen, F, Andrés, AM, Siegismund, HR, Scally, A, Excoffier, L, Tyler-Smith, C, Castellano, S, Xue, Y, Hvilsom, C & Marques-Bonet, T 2016, 'Chimpanzee genomic diversity reveals ancient admixture with bonobos', Science, vol. 354, no. 6311, pp. 477-481. https://doi.org/10.1126/science.aag2602
De Manuel M, Kuhlwilm M, Frandsen P, Sousa VC, Desai T, Prado-Martinez J et al. Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science. 2016 Oct 28;354(6311):477-481. https://doi.org/10.1126/science.aag2602
De Manuel, Marc ; Kuhlwilm, Martin ; Frandsen, Peter ; Sousa, Vitor C. ; Desai, Tariq ; Prado-Martinez, Javier ; Hernandez-Rodriguez, Jessica ; Dupanloup, Isabelle ; Lao, Oscar ; Hallast, Pille ; Schmidt, Joshua M. ; Heredia-Genestar, José María ; Benazzo, Andrea ; Barbujani, Guido ; Peter, Benjamin M. ; Kuderna, Lukas F K ; Casals, Ferran ; Angedakin, Samuel ; Arandjelovic, Mimi ; Boesch, Christophe ; Kühl, Hjalmar ; Vigilant, Linda ; Langergraber, Kevin ; Novembre, John ; Gut, Marta ; Gut, Ivo ; Navarro, Arcadi ; Carlsen, Frands ; Andrés, Aida M. ; Siegismund, Hans R. ; Scally, Aylwyn ; Excoffier, Laurent ; Tyler-Smith, Chris ; Castellano, Sergi ; Xue, Yali ; Hvilsom, Christina ; Marques-Bonet, Tomas. / Chimpanzee genomic diversity reveals ancient admixture with bonobos. In: Science. 2016 ; Vol. 354, No. 6311. pp. 477-481.
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