Chemotherapy of human tumor xenografts in genetically athymic mice

A. A. Ovejera, D. P. Houchens, Anna Barker

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

A series of studies were undertaken to evaluate the chemotherapeutic response to various antineoplastic drugs of human breast (MX-1) or colon (CX-2) tumor xenografts growing in genetically athymic (nude) mice. Fragments (2mm3) of either tumor type were implanted subcutaneously into the subaxillary region of NIH Swiss nude mice, and single drug therapy was started when tumors became palpable and were growing progressively. 5-Fluorouracil (5-FU) administered on a Q7DX3 schedule starting on Day 21 post tumor implantation elicited significant retardation in the growth rate of CX-2 tumor. A single treatment with methyl-CCNU induced temporary tumor regression. Against MX-1 tumor, both cyclophosphamide and melphalan induced tumor regressions with no recurrence. 5-FU slowed but did not arrest growth of MX-1 tumor. These tumor systems grown in nude mice appear to be suitable models for in vivo screening of anticancer agents that would prove clinically active.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalAnnals of Clinical and Laboratory Science
Volume8
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Chemotherapy
Heterografts
Nude Mice
Tumors
Drug Therapy
Neoplasms
Fluorouracil
Antineoplastic Agents
Semustine
Drug therapy
Melphalan
Growth
Cyclophosphamide
Appointments and Schedules
Screening
Colon
Breast
Recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

Cite this

Chemotherapy of human tumor xenografts in genetically athymic mice. / Ovejera, A. A.; Houchens, D. P.; Barker, Anna.

In: Annals of Clinical and Laboratory Science, Vol. 8, No. 1, 1978, p. 50-56.

Research output: Contribution to journalArticle

Ovejera, AA, Houchens, DP & Barker, A 1978, 'Chemotherapy of human tumor xenografts in genetically athymic mice', Annals of Clinical and Laboratory Science, vol. 8, no. 1, pp. 50-56.
Ovejera, A. A. ; Houchens, D. P. ; Barker, Anna. / Chemotherapy of human tumor xenografts in genetically athymic mice. In: Annals of Clinical and Laboratory Science. 1978 ; Vol. 8, No. 1. pp. 50-56.
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