@inbook{44a2d998f2614bb0a99943a098d7e5e4,
title = "Chemokine oligomerization in cell signaling and migration",
abstract = "Chemokines are small proteins best known for their role in controlling the migration of diverse cells, particularly leukocytes. Upon binding to their G-protein-coupled receptors on the leukocytes, chemokines stimulate the signaling events that cause cytoskeletal rearrangements involved in cell movement, and migration of the cells along chemokine gradients. Depending on the cell type, chemokines also induce many other types of cellular responses including those related to defense mechanisms, cell proliferation, survival, and development. Historically, most research efforts have focused on the interaction of chemokines with their receptors, where monomeric forms of the ligands are the functionally relevant state. More recently, however, the importance of chemokine interactions with cell surface glycosaminoglycans has come to light, and in most cases appears to involve oligomeric chemokine structures. This review summarizes existing knowledge relating to the structure and function of chemokine oligomers, and emerging methodology for determining structures of complex chemokine assemblies in the future.",
keywords = "Cell migration, Chemokine, Chemokine receptor, Glycosaminoglycan, Mass spectrometry, Nuclear magnetic resonance, Oligomerization, Small angle X-ray scattering, Structure",
author = "Xu Wang and Sharp, {Joshua S.} and Handel, {Tracy M.} and Prestegard, {James H.}",
note = "Funding Information: Financial support for this work was provided by NIH grants from the National Center for Research Resources (5 P41 RR005351-23) and the National Institute of General Medical Sciences (8 P41 GM103390-23), in support of the Resource for Integrated Glycotechnology at the University of Georgia and from the National Institute of General Medical Sciences (U01 GM094612) and the National Institute of Allergy and Infectious Diseases (R01 AI37113-14) in support of research at the University of California San Diego. ",
year = "2013",
doi = "10.1016/B978-0-12-386931-9.00020-9",
language = "English (US)",
isbn = "9780123869319",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "531--578",
booktitle = "Oligomerization in Health and Disease",
}