Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts

Eric L.R. Bédard, Peter Kim, Jifu Jiang, Neil Parry, Liying Liu, Hao Wang, Bertha Garcia, Xing Li, Douglas McFadden, Alexandra Lucas, Robert Zhong

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

M-T7 is a myxoma virus-encoded protein that has been found to bind and disrupt human chemokine gradients. This study examined whether purified M-T7 could prevent chronic rejection in a rat renal allograft model. Fisher F344 renal allografts were transplanted into Lewis rats. Recipients were randomly grouped into two groups: control animals treated with cyclosporine alone and animals treated with cyclosporine combined with low-, medium- and high-dose M-T7 viral protein. The survival rate was not significantly different between allograft groups. Renal allografts treated with high-dose M-T7 demonstrated a significant reduction in tubular atrophy, glomerular atrophy, vascular hyalinization, cortical scarring, and lymphocyte infiltration. Morphometric analyses demonstrated that the high-dose M-T7 group also showed a significantly decreased amount of glomerulosclerosis and transplant arteriosclerosis. These data demonstrate for the first time that the immunoregulatory viral protein M-T7 can effectively attenuate chronic rejection in rat renal allografts.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalTransplantation
Volume76
Issue number1
DOIs
StatePublished - Jul 15 2003
Externally publishedYes

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Viral Proteins
Chemokines
Allografts
Carrier Proteins
Kidney
Viral Matrix Proteins
Cyclosporine
Atrophy
Myxoma virus
Arteriosclerosis
Cicatrix
Blood Vessels
Lymphocytes
Transplants
Control Groups
Proteins

ASJC Scopus subject areas

  • Transplantation

Cite this

Bédard, E. L. R., Kim, P., Jiang, J., Parry, N., Liu, L., Wang, H., ... Zhong, R. (2003). Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts. Transplantation, 76(1), 249-252. https://doi.org/10.1097/01.TP.0000061604.57432.E3

Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts. / Bédard, Eric L.R.; Kim, Peter; Jiang, Jifu; Parry, Neil; Liu, Liying; Wang, Hao; Garcia, Bertha; Li, Xing; McFadden, Douglas; Lucas, Alexandra; Zhong, Robert.

In: Transplantation, Vol. 76, No. 1, 15.07.2003, p. 249-252.

Research output: Contribution to journalArticle

Bédard, ELR, Kim, P, Jiang, J, Parry, N, Liu, L, Wang, H, Garcia, B, Li, X, McFadden, D, Lucas, A & Zhong, R 2003, 'Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts', Transplantation, vol. 76, no. 1, pp. 249-252. https://doi.org/10.1097/01.TP.0000061604.57432.E3
Bédard, Eric L.R. ; Kim, Peter ; Jiang, Jifu ; Parry, Neil ; Liu, Liying ; Wang, Hao ; Garcia, Bertha ; Li, Xing ; McFadden, Douglas ; Lucas, Alexandra ; Zhong, Robert. / Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts. In: Transplantation. 2003 ; Vol. 76, No. 1. pp. 249-252.
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