Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Indrajit Bandyopadhyay, Sandipan Roy Chowdhury, Nishant P. Visavadiya, Sidney Hecht, Omar Khdour

Research output: Contribution to journalArticle

Abstract

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

Original languageEnglish (US)
Pages (from-to)1105-1114
Number of pages10
JournalData in Brief
Volume20
DOIs
StatePublished - Oct 1 2018

Fingerprint

Neurodegenerative diseases
Methylene Blue
frataxin

ASJC Scopus subject areas

  • General

Cite this

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels. / Bandyopadhyay, Indrajit; Chowdhury, Sandipan Roy; Visavadiya, Nishant P.; Hecht, Sidney; Khdour, Omar.

In: Data in Brief, Vol. 20, 01.10.2018, p. 1105-1114.

Research output: Contribution to journalArticle

Bandyopadhyay, Indrajit ; Chowdhury, Sandipan Roy ; Visavadiya, Nishant P. ; Hecht, Sidney ; Khdour, Omar. / Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels. In: Data in Brief. 2018 ; Vol. 20. pp. 1105-1114.
@article{f86dc8e994b9401b8345a501a2e69bcd,
title = "Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels",
abstract = "As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.",
author = "Indrajit Bandyopadhyay and Chowdhury, {Sandipan Roy} and Visavadiya, {Nishant P.} and Sidney Hecht and Omar Khdour",
year = "2018",
month = "10",
day = "1",
doi = "10.1016/j.dib.2018.08.156",
language = "English (US)",
volume = "20",
pages = "1105--1114",
journal = "Data in Brief",
issn = "2352-3409",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

AU - Bandyopadhyay, Indrajit

AU - Chowdhury, Sandipan Roy

AU - Visavadiya, Nishant P.

AU - Hecht, Sidney

AU - Khdour, Omar

PY - 2018/10/1

Y1 - 2018/10/1

N2 - As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

AB - As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

UR - http://www.scopus.com/inward/record.url?scp=85053182577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053182577&partnerID=8YFLogxK

U2 - 10.1016/j.dib.2018.08.156

DO - 10.1016/j.dib.2018.08.156

M3 - Article

AN - SCOPUS:85053182577

VL - 20

SP - 1105

EP - 1114

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

ER -