Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Indrajit Bandyopadhyay, Sandipan Roy Chowdhury, Nishant P. Visavadiya, Sidney Hecht, Omar Khdour

Research output: Contribution to journalArticle

Abstract

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

Original languageEnglish (US)
Pages (from-to)1105-1114
Number of pages10
JournalData in Brief
Volume20
DOIs
StatePublished - Oct 2018

ASJC Scopus subject areas

  • General

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