Chemical modifications of transfer RNA species. Heavy atom derivatization of aminoacyl tRNA

Francis J. Schmidt, Robert M. Bock, Sidney M. Hecht

Research output: Contribution to journalArticle

12 Scopus citations


Specific heavy atom derivatization of valyl and arginyl tRNA's from E. coli has been effected by the use of the N-hydroxysuccinimide esters of certain carboxylic acids. The derivatized tRNA's have been separated from underivatized material and shown to be stable under the conditions required for crystallization.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jul 25 1972


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this