The number of charge changes relative to total amino acid replacements for each of seven protein sequences (cytochrome c, hemoglobin α, hemoglobin β, myoglobin, insulin, and fibrinopeptides A and B) has been studied. This number was compared with the expected value obtained under the assumption of random nucleotide substitution. The results obtained indicate that four proteins - hemoglobin α, hemoglobin β, myoglobin, and insulin - are accumulating charge changes at rates slower than those predicted by a model of random substitution. Cytochrome c and fibrinopeptides A and B are accumulating charge changes at rates similar to those predicted by a random model.
|Original language||English (US)|
|Number of pages||11|
|Journal||Molecular biology and evolution|
|State||Published - 1986|
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology