Characterizing the influence of effective population size on the rate of adaptation: Gillespie's Darwin domain

Jeffrey Jensen, Doris Bachtrog

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Characterizing the role of effective population size in dictating the rate of adaptive evolution remains a major challenge in evolutionary biology. Depending on the underlying distribution of fitness effects of new mutations, populations of different sizes may differ vastly in their rate of adaptation. Here, we collect polymorphism data at over 100 loci for two closely related Drosophila species with different current effective population sizes (N e), Drosophila miranda and D. pseudoobscura, to evaluate the prevalence of adaptive evolution versus genetic drift in molecular evolution. Utilizing these large and consistently sampled data sets, we obtain greatly improved estimates of the demographic histories of both species. Specifically, although current N e differs between these species, their ancestral sizes were much more similar. We find that statistical approaches capturing recent adaptive evolution (using patterns of polymorphisms) detect higher rates of adaptive evolution in the larger D. pseudoobscura population. In contrast, methods aimed at detecting selection over longer time periods (i.e., those relying on divergence data) estimate more similar rates of adaptation between the two species. Thus, our results suggest an important role of effective population size in dictating rates of adaptation and highlight how complicated population histories-as is probably the case for most species-can effect rates of adaptation. Additionally, we also show how different methodologies to detect positive selection can reveal information about different timescales of adaptive evolution.

Original languageEnglish (US)
Pages (from-to)687-701
Number of pages15
JournalGenome Biology and Evolution
Volume3
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

effective population size
Population Density
population size
Drosophila
Genetic Drift
Molecular Evolution
polymorphism
genetic polymorphism
Population
Drosophila pseudoobscura
demographic history
history
genetic drift
evolutionary biology
Demography
cans
Mutation
rate
mutation
fitness

Keywords

  • Demography
  • Natural selection
  • Selective sweeps

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cite this

Characterizing the influence of effective population size on the rate of adaptation : Gillespie's Darwin domain. / Jensen, Jeffrey; Bachtrog, Doris.

In: Genome Biology and Evolution, Vol. 3, No. 1, 2011, p. 687-701.

Research output: Contribution to journalArticle

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