Characterization of three VNTR systems at D21S112

Norma Takaesu; Stuart Newfeld; Terry Hassold

doi:10.1016/S0888-7543(05)80197-1

Characterization of three VNTR systems at D21S112

Norma Takaesu, Stuart Newfeld, Terry Hassold

Research output: Contribution to journal › Article › peer-review

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Abstract

D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome.

Original language	English (US)
Pages (from-to)	816-817
Number of pages	2
Journal	Genomics
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/S0888-7543(05)80197-1
State	Published - Nov 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/S0888-7543(05)80197-1

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title = "Characterization of three VNTR systems at D21S112",

abstract = "D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome.",

author = "Norma Takaesu and Stuart Newfeld and Terry Hassold",

note = "Funding Information: This work was supported by NIH Contract N01-HD 92707.",

year = "1992",

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doi = "10.1016/S0888-7543(05)80197-1",

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T1 - Characterization of three VNTR systems at D21S112

AU - Takaesu, Norma

AU - Newfeld, Stuart

AU - Hassold, Terry

N1 - Funding Information: This work was supported by NIH Contract N01-HD 92707.

PY - 1992/11

Y1 - 1992/11

N2 - D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome.

AB - D21S112 is a highly polymorphic marker on the long arm of chromosome 21. Our analysis of this locus indicated the presence of three VNTR systems. We estimated the heterozygosity of each system and sequenced one of the repetitive regions. Utilizing PCR, we demonstrated that the sequenced VNTR is responsible for the system with the highest level of heterozygosity. Combining data from the three systems makes D21S112 one of the most informative loci on the chromosome.

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JO - Genomics

JF - Genomics

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Characterization of three VNTR systems at D21S112

Abstract

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