Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J. Padanilam; H. S. Stadler; K. A. Mills; L. B. Mcleod; M. Solursh; B. Lee; F. Ramirez; K. H. Buetow; J. C. Murray

doi:10.1093/hmg/1.6.407

Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J. Padanilam, H. S. Stadler, K. A. Mills, L. B. Mcleod, M. Solursh, B. Lee, F. Ramirez, K. H. Buetow, J. C. Murray

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

Original language	English (US)
Pages (from-to)	407-410
Number of pages	4
Journal	Human Molecular Genetics
Volume	1
Issue number	6
DOIs	https://doi.org/10.1093/hmg/1.6.407
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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title = "Characterization of the human HOX 7 cDNA and identification of polymorphic markers",

abstract = "cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.",

author = "Padanilam, {B. J.} and Stadler, {H. S.} and Mills, {K. A.} and Mcleod, {L. B.} and M. Solursh and B. Lee and F. Ramirez and Buetow, {K. H.} and Murray, {J. C.}",

note = "Funding Information: The technical assistance of Dee Ann Even is gratefully appreciated. BJP, LBM, HSS and MS were supported by (NIH DE09170). KAM, KHB and JCM were supported by NIH HGOO355, DEO917O, DK25295. This is article #114 from the Brookdale Center of Molecular Biology at the Mt. Sinai School of Medicine.",

year = "1992",

month = sep,

doi = "10.1093/hmg/1.6.407",

language = "English (US)",

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journal = "Human Molecular Genetics",

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T1 - Characterization of the human HOX 7 cDNA and identification of polymorphic markers

AU - Padanilam, B. J.

AU - Stadler, H. S.

AU - Mills, K. A.

AU - Mcleod, L. B.

AU - Solursh, M.

AU - Lee, B.

AU - Ramirez, F.

AU - Buetow, K. H.

AU - Murray, J. C.

N1 - Funding Information: The technical assistance of Dee Ann Even is gratefully appreciated. BJP, LBM, HSS and MS were supported by (NIH DE09170). KAM, KHB and JCM were supported by NIH HGOO355, DEO917O, DK25295. This is article #114 from the Brookdale Center of Molecular Biology at the Mt. Sinai School of Medicine.

PY - 1992/9

Y1 - 1992/9

N2 - cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

AB - cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

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Characterization of the human HOX 7 cDNA and identification of polymorphic markers

Abstract

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