Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications

Andrew W. Holle, Shih-Hui Chao, Mark R. Holl, Jeffrey M. Houkal, Deirdre Meldrum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

PDMS (polydimethylsiloxane) is an important material for lab-on-a-chip, an emerging technology to automate biological and chemical operations in microfluidic devices. Laser manufacturing of materials suitable for use in laminate-based construction of lab-on-a-chip devices is an important step in the development of automated assembly line procedures. This study investigates the effect of laser cutting parameters on channel topography when a carbon dioxide laser is used to create trenches in PDMS. We present cross-sectional micrographs of the laser-ablated channels that reveal a modified Gaussian contour, with smooth, circular arcs at the bottom of the channel. We define geometric parameters that describe the contours, including cut depth and maximum cut width. Relationships between laser power, pulses per inch, and laser traverse speed and ablation profile patterns are established. A strong linear relationship (R2=0.9951) between cut depth and laser power is demonstrated. Analysis of the radii of circular arcs at the bottom of the channel and at the surface of the PDMS was performed. As laser power density is increased (increase in laser power or pulses per inch) the PDMS surface radii and channel floor radius decrease.

Original languageEnglish (US)
Title of host publicationProceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
Pages621-627
Number of pages7
DOIs
StatePublished - 2007
Event3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007 - Scottsdale, AZ, United States
Duration: Sep 22 2007Sep 25 2007

Other

Other3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
CountryUnited States
CityScottsdale, AZ
Period9/22/079/25/07

Fingerprint

Lab-on-a-chip
Polydimethylsiloxane
Lasers
Laser pulses
Chemical operations
Carbon dioxide lasers
Ablation
Microfluidics
Topography
Laminates

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Holle, A. W., Chao, S-H., Holl, M. R., Houkal, J. M., & Meldrum, D. (2007). Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications. In Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007 (pp. 621-627). [4341853] https://doi.org/10.1109/COASE.2007.4341853

Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications. / Holle, Andrew W.; Chao, Shih-Hui; Holl, Mark R.; Houkal, Jeffrey M.; Meldrum, Deirdre.

Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007. 2007. p. 621-627 4341853.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Holle, AW, Chao, S-H, Holl, MR, Houkal, JM & Meldrum, D 2007, Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications. in Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007., 4341853, pp. 621-627, 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007, Scottsdale, AZ, United States, 9/22/07. https://doi.org/10.1109/COASE.2007.4341853
Holle AW, Chao S-H, Holl MR, Houkal JM, Meldrum D. Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications. In Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007. 2007. p. 621-627. 4341853 https://doi.org/10.1109/COASE.2007.4341853
Holle, Andrew W. ; Chao, Shih-Hui ; Holl, Mark R. ; Houkal, Jeffrey M. ; Meldrum, Deirdre. / Characterization of program controlled CO2 laser-cut PDMS channels for lab-on-a-chip applications. Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007. 2007. pp. 621-627
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