Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases

Robert W. Hamill; William R. Markesbery; Keith McDaniel; Paul D. Coleman

doi:10.1016/0197-4580(93)90037-C

Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases

Robert W. Hamill, William R. Markesbery, Keith McDaniel, Paul D. Coleman

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

We review current understanding of the clinical and pathologic information needed for the determination of optimal brain tissue samples for the conduct of studies of Alzheimer's disease (AD). Characteristics that may distinguish AD from other dementing disorders are discussed. Selected considerations in the conduct of basic neurobiological studies are also outlined. Although the 28 NIA-funded Alzheimer's Centers can provide excellent clinical and neuropathological data, studies conducted outside these centers should also strive to gather the information suggested here. Clinical and neuropathological data should be used not only to classify subjects as control or AD, but also as variables that may significantly contribute to the analysis of neurobiological data obtained in the laboratory.

Original language	English (US)
Pages (from-to)	539-545
Number of pages	7
Journal	Neurobiology of Aging
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/0197-4580(93)90037-C
State	Published - 1993
Externally published	Yes

Keywords

Alzheimer's disease
Brain samples
Diagnosis
Neuropathology

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(93)90037-C

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title = "Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases",

abstract = "We review current understanding of the clinical and pathologic information needed for the determination of optimal brain tissue samples for the conduct of studies of Alzheimer's disease (AD). Characteristics that may distinguish AD from other dementing disorders are discussed. Selected considerations in the conduct of basic neurobiological studies are also outlined. Although the 28 NIA-funded Alzheimer's Centers can provide excellent clinical and neuropathological data, studies conducted outside these centers should also strive to gather the information suggested here. Clinical and neuropathological data should be used not only to classify subjects as control or AD, but also as variables that may significantly contribute to the analysis of neurobiological data obtained in the laboratory.",

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T1 - Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases

AU - Hamill, Robert W.

AU - Markesbery, William R.

AU - McDaniel, Keith

AU - Coleman, Paul D.

PY - 1993

Y1 - 1993

N2 - We review current understanding of the clinical and pathologic information needed for the determination of optimal brain tissue samples for the conduct of studies of Alzheimer's disease (AD). Characteristics that may distinguish AD from other dementing disorders are discussed. Selected considerations in the conduct of basic neurobiological studies are also outlined. Although the 28 NIA-funded Alzheimer's Centers can provide excellent clinical and neuropathological data, studies conducted outside these centers should also strive to gather the information suggested here. Clinical and neuropathological data should be used not only to classify subjects as control or AD, but also as variables that may significantly contribute to the analysis of neurobiological data obtained in the laboratory.

AB - We review current understanding of the clinical and pathologic information needed for the determination of optimal brain tissue samples for the conduct of studies of Alzheimer's disease (AD). Characteristics that may distinguish AD from other dementing disorders are discussed. Selected considerations in the conduct of basic neurobiological studies are also outlined. Although the 28 NIA-funded Alzheimer's Centers can provide excellent clinical and neuropathological data, studies conducted outside these centers should also strive to gather the information suggested here. Clinical and neuropathological data should be used not only to classify subjects as control or AD, but also as variables that may significantly contribute to the analysis of neurobiological data obtained in the laboratory.

KW - Alzheimer's disease

KW - Brain samples

KW - Diagnosis

KW - Neuropathology

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DO - 10.1016/0197-4580(93)90037-C

M3 - Comment/debate

C2 - 8295656

AN - SCOPUS:0027493750

SN - 0197-4580

VL - 14

SP - 539

EP - 545

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 6

ER -

Characterization of brain samples in studies of aging, Alzheimer's, and other neurodegenerative diseases

Abstract

Keywords

ASJC Scopus subject areas

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