Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption

Seokheun Choi; Wencheng Xu; Xu Zhang; Junseok Chae

doi:10.1109/MEMSYS.2010.5442302

Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption

Seokheun Choi, Wencheng Xu, Xu Zhang, Junseok Chae

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

We report the characterization results of in-liquid longitudinal-mode FBAR (L-FBAR) for real-time in-situ monitoring of the Vroman effect, a competitive adsorption and exchange of proteins on a surface. The change of resonant frequency of the L-FBAR, -1.55 GHz, is a direct function of the proteins' molecular weight, and thus we monitor the resonant frequency shifts to estimate the adsorption and exchange behavior. A low molecular weight (LMW) protein, albumin, initially covers the surface and is displaced by a high molecular weight (HMW) protein, IgG; sequentially, the highest molecular weight protein, fibrinogen displaces IgG. However, the reverse sequence does not occur.

Original language	English (US)
Title of host publication	MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest
Pages	739-742
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2010.5442302
State	Published - Jun 1 2010
Event	23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010 - Hong Kong, China Duration: Jan 24 2010 → Jan 28 2010

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010
Country	China
City	Hong Kong
Period	1/24/10 → 1/28/10

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2010.5442302

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Choi, S., Xu, W., Zhang, X., & Chae, J. (2010). Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption. In MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest (pp. 739-742). [5442302] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2010.5442302

Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption. / Choi, Seokheun; Xu, Wencheng; Zhang, Xu; Chae, Junseok.

MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. 2010. p. 739-742 5442302 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Choi, S, Xu, W, Zhang, X & Chae, J 2010, Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption. in MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest., 5442302, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 739-742, 23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010, Hong Kong, China, 1/24/10. https://doi.org/10.1109/MEMSYS.2010.5442302

Choi S, Xu W, Zhang X, Chae J. Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption. In MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. 2010. p. 739-742. 5442302. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2010.5442302

Choi, Seokheun ; Xu, Wencheng ; Zhang, Xu ; Chae, Junseok. / Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption. MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. 2010. pp. 739-742 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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abstract = "We report the characterization results of in-liquid longitudinal-mode FBAR (L-FBAR) for real-time in-situ monitoring of the Vroman effect, a competitive adsorption and exchange of proteins on a surface. The change of resonant frequency of the L-FBAR, -1.55 GHz, is a direct function of the proteins' molecular weight, and thus we monitor the resonant frequency shifts to estimate the adsorption and exchange behavior. A low molecular weight (LMW) protein, albumin, initially covers the surface and is displaced by a high molecular weight (HMW) protein, IgG; sequentially, the highest molecular weight protein, fibrinogen displaces IgG. However, the reverse sequence does not occur.",

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