TY - JOUR
T1 - Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease
AU - Flood, Dorothy G.
AU - Coleman, Paul D.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Different patterns of age-related dendritic change have been reported in different zones of the human hippocampal region in the normal and Alzheimer's disease (AD) brain. In normal aging there is an increase in average (net) dendritic extent (which we interpret as plasticity) in the parahippocampal gyrus and dentate gyrus. There is net stability of dendritic extent in CA2–3, CA1, and subiculum. In regions that show plasticity in normal aging, dendrites in AD show reduced or aberrant plasticity. In regions that show stability in normal aging, dendrites either are stable or regress in AD, depending upon how severely involved the region is with the pathology of AD.
AB - Different patterns of age-related dendritic change have been reported in different zones of the human hippocampal region in the normal and Alzheimer's disease (AD) brain. In normal aging there is an increase in average (net) dendritic extent (which we interpret as plasticity) in the parahippocampal gyrus and dentate gyrus. There is net stability of dendritic extent in CA2–3, CA1, and subiculum. In regions that show plasticity in normal aging, dendrites in AD show reduced or aberrant plasticity. In regions that show stability in normal aging, dendrites either are stable or regress in AD, depending upon how severely involved the region is with the pathology of AD.
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U2 - 10.1016/S0079-6123(08)61267-4
DO - 10.1016/S0079-6123(08)61267-4
M3 - Article
C2 - 2203107
AN - SCOPUS:0025281641
SN - 0079-6123
VL - 83
SP - 435
EP - 443
JO - Progress in brain research
JF - Progress in brain research
IS - C
ER -