CHAPTER 9: Big Data Integration and Inference

Karen H. Watanabe-Sailor, Hristo Aladjov, Shannon M. Bell, Lyle Burgoon, Wan Yun Cheng, Rory Conolly, Stephen W. Edwards, Nàtalia Garcia-Reyero, Michael L. Mayo, Anthony Schroeder, Clemens Wittwehr, Edward J. Perkins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Toxicology data are generated on large scales by toxicogenomic studies and high-throughput screening (HTS) programmes, and on smaller scales by traditional methods. Both big and small data have value for elucidating toxicological mechanisms and pathways that are perturbed by chemical stressors. In addition, years of investigations comprise a wealth of knowledge as reported in the literature that is also used to interpret new data, though knowledge is not often captured in traditional databases. With the big data era, computer automation to analyse and interpret datasets is needed, which requires aggregation of data and knowledge from all available sources. This chapter reviews ongoing efforts to aggregate toxicological knowledge in a knowledge base, based on the Adverse Outcome Pathways framework, and provides examples of data integration and inferential analysis for use in (predictive) toxicology.

Original languageEnglish (US)
Title of host publicationBig Data in Predictive Toxicology
EditorsDaniel Neagu, Andrea-Nicole Richarz
PublisherRoyal Society of Chemistry
Pages264-306
Number of pages43
Edition41
DOIs
StatePublished - Jan 1 2020

Publication series

NameIssues in Toxicology
Number41
Volume2020-January
ISSN (Print)1757-7179
ISSN (Electronic)1757-7187

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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    Watanabe-Sailor, K. H., Aladjov, H., Bell, S. M., Burgoon, L., Cheng, W. Y., Conolly, R., Edwards, S. W., Garcia-Reyero, N., Mayo, M. L., Schroeder, A., Wittwehr, C., & Perkins, E. J. (2020). CHAPTER 9: Big Data Integration and Inference. In D. Neagu, & A-N. Richarz (Eds.), Big Data in Predictive Toxicology (41 ed., pp. 264-306). (Issues in Toxicology; Vol. 2020-January, No. 41). Royal Society of Chemistry. https://doi.org/10.1039/9781782623656-00264