Abstract
Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.
| Original language | English (US) |
|---|---|
| Journal | Journal of Adolescent Health |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Adolescents
- Microbiota
- Obesity
- Students
- Waist circumference
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Public Health, Environmental and Occupational Health
- Psychiatry and Mental health
Cite this
Changes in Weight Status and the Intestinal Microbiota Among College Freshman, Aged 18 Y. / Journey, Elizabeth K.; Ortega-Santos, Carmen P.; Bruening, Meredith; Whisner, Corrie.
In: Journal of Adolescent Health, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in Weight Status and the Intestinal Microbiota Among College Freshman, Aged 18 Y
AU - Journey, Elizabeth K.
AU - Ortega-Santos, Carmen P.
AU - Bruening, Meredith
AU - Whisner, Corrie
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.
AB - Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.
KW - Adolescents
KW - Microbiota
KW - Obesity
KW - Students
KW - Waist circumference
UR - http://www.scopus.com/inward/record.url?scp=85071516304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071516304&partnerID=8YFLogxK
U2 - 10.1016/j.jadohealth.2019.06.005
DO - 10.1016/j.jadohealth.2019.06.005
M3 - Article
AN - SCOPUS:85071516304
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
SN - 1054-139X
ER -