Abstract

Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.

Original languageEnglish (US)
JournalJournal of Adolescent Health
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Waist Circumference
Body Mass Index
Weights and Measures
Weight Gain
Multivariate Analysis
Regression Analysis
Observational Studies
Real-Time Polymerase Chain Reaction
Obesity
Outcome Assessment (Health Care)
Gastrointestinal Microbiome
Population

Keywords

  • Adolescents
  • Microbiota
  • Obesity
  • Students
  • Waist circumference

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

Cite this

Changes in Weight Status and the Intestinal Microbiota Among College Freshman, Aged 18 Y. / Journey, Elizabeth K.; Ortega-Santos, Carmen P.; Bruening, Meredith; Whisner, Corrie.

In: Journal of Adolescent Health, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Changes in Weight Status and the Intestinal Microbiota Among College Freshman, Aged 18 Y",
abstract = "Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.",
keywords = "Adolescents, Microbiota, Obesity, Students, Waist circumference",
author = "Journey, {Elizabeth K.} and Ortega-Santos, {Carmen P.} and Meredith Bruening and Corrie Whisner",
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AU - Journey, Elizabeth K.

AU - Ortega-Santos, Carmen P.

AU - Bruening, Meredith

AU - Whisner, Corrie

PY - 2019/1/1

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N2 - Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.

AB - Purpose: The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre–post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39). Methods: We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015–2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses. Results: A total of 24 female and 15 male adolescents (aged 18.54 ±.67 years) participated in this study. Over the academic year, BMI and WC increased by.97±1.28 kg/m2 and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = −.66, p <.01; and r = −.33, p =.04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R2 =.53, p <.01; and R2 =.24, p =.15, respectively). Conclusions: As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.

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