Changes in susceptibility of normal cells to agglutination by plant lectins following modification of cell coat material

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Infection of normal chick embryo, baby hamster kidney and HEp-2 cells with the nononcogenic viruses, Newcastle disease virus and Herpes simplex virus, was found to increase their susceptibility to agglutination by the plant lectins, concanavalin A and wheat germ agglutinin. Similar results were obtained following treatment of normal HEp-2 cells with anticellular serum and high concentrations of vitamin A alcohol. The agglutination reaction with concanavalin A and wheat germ agglutinin was inhibited specifically by α-methyl-d-glucopyranoside and N-acetyl-glucosamine, respectively. A temporal correlation was demonstrated between changes in cell agglutination behaviour and digestion of the cell coat material. The relationship of changes occurring in the cell coat to the observed alterations in cell agglutination behaviour was discussed with reference to the role of enzymic modification of the cell periphery as a factor in cell growth regulation.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalExperimental Cell Research
Issue number2
StatePublished - Aug 1972


ASJC Scopus subject areas

  • Cell Biology

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