Changes in neurocranium thickness in early childhood

Niharika Gajawelli, Sean Deoni, Jie Shi, Liang Xu, Holly Dirks, Douglas Dean, Jonathan O'Muircheartaigh, Siddhant Sawardekar, Andrea Ezis, Marvin D. Nelson, Yalin Wang, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several developmental disorders involve shape abnormalities of the neurocranium, the most common one being craniosynostosis, that affects about 1 in 2000 infants. A key step in determining how these disorders affect neurodevelopment is to establish how the brain and neurocranium co-evolve in the normally developing child. However, due to the scarcity of normally developing infant and pediatric imaging data, there have been a lack of imaging studies pertaining to normal neurocranial development. Here, taking advantage of a large data bank of high quality brain MRI from healthy children ages 0-4 years old, and of a novel conformal geometry-based analysis pipeline, we have been determining a set of statistical atlases of the neurocranium, divided into age groups. In this first part of the study, we focus more specifically on a comparison of 1 and 2 year old infants. Characterizing neurocranium shape changes will enable us to understand how the cranial bones develop in relation to brain development. This in turn will allow a better determination of the effects of neurocranial disorders, which will help inform treatment strategies.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSPIE
Volume9681
ISBN (Print)9781628419160
DOIs
StatePublished - 2015
Event11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015 - Cuenca, Ecuador
Duration: Nov 17 2015Nov 19 2015

Other

Other11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015
CountryEcuador
CityCuenca
Period11/17/1511/19/15

Fingerprint

brain
Disorder
Brain
disorders
Imaging
Conformal Geometry
Imaging techniques
Pediatrics
Atlas
Large Data
abnormalities
Bone
Magnetic resonance imaging
bones
Pipelines
Geometry
geometry
Children
Strategy
Banks

Keywords

  • brain
  • neonatal/pediatric imaging
  • Neurocranium

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Gajawelli, N., Deoni, S., Shi, J., Xu, L., Dirks, H., Dean, D., ... Lepore, N. (2015). Changes in neurocranium thickness in early childhood. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 9681). [96810I] SPIE. https://doi.org/10.1117/12.2211502

Changes in neurocranium thickness in early childhood. / Gajawelli, Niharika; Deoni, Sean; Shi, Jie; Xu, Liang; Dirks, Holly; Dean, Douglas; O'Muircheartaigh, Jonathan; Sawardekar, Siddhant; Ezis, Andrea; Nelson, Marvin D.; Wang, Yalin; Lepore, Natasha.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9681 SPIE, 2015. 96810I.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gajawelli, N, Deoni, S, Shi, J, Xu, L, Dirks, H, Dean, D, O'Muircheartaigh, J, Sawardekar, S, Ezis, A, Nelson, MD, Wang, Y & Lepore, N 2015, Changes in neurocranium thickness in early childhood. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 9681, 96810I, SPIE, 11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015, Cuenca, Ecuador, 11/17/15. https://doi.org/10.1117/12.2211502
Gajawelli N, Deoni S, Shi J, Xu L, Dirks H, Dean D et al. Changes in neurocranium thickness in early childhood. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9681. SPIE. 2015. 96810I https://doi.org/10.1117/12.2211502
Gajawelli, Niharika ; Deoni, Sean ; Shi, Jie ; Xu, Liang ; Dirks, Holly ; Dean, Douglas ; O'Muircheartaigh, Jonathan ; Sawardekar, Siddhant ; Ezis, Andrea ; Nelson, Marvin D. ; Wang, Yalin ; Lepore, Natasha. / Changes in neurocranium thickness in early childhood. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9681 SPIE, 2015.
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