Challenging the Inevitability of Prostate Enlargement: Low Levels of Benign Prostatic Hyperplasia among Tsimane Forager-Horticulturalists

Benjamin Trumble, Jonathan Stieglitz, Daniel Eid Rodriguez, Edhitt Cortez Linares, Hillard S. Kaplan, Michael D. Gurven

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Often considered an inevitable part of male aging, benign prostatic hyperplasia (BPH) is the most common non-life threatening disease to affect men in Western populations. We examine age-related change in prostate size and BPH risk and related serum biomarkers among the Tsimane Amerindians of the Bolivian Amazon who live a traditional lifestyle of hunting and small-scale horticulture. The Tsimane are a critical case study for understanding the etiology of BPH as they have low levels of obesity and metabolic syndrome, as well as lower levels of testosterone than age matched U.S. males, factors associated with BPH in previous research. Methods. Ultrasounds were conducted on 348 men aged 28-89 years (median age 56 years). Testosterone, prostate specific antigen, sex hormone binding globulin, and glycosylated hemoglobin were examined in relationship to prostate size and BPH. Results. Tsimane have less than half of the BPH prevalence experienced by U.S. men, and prostate volumes 62.6% smaller. While Tsimane have low levels of testosterone and subclinical levels of metabolic syndrome compared to U.S. men, Tsimane with high testosterone were more likely to experience BPH, as were those with higher glycosylated hemoglobin, suggesting targets for clinical interventions to reduce BPH. Conclusions. These results have clinical significance for the growing number of men taking testosterone supplementation; even at low levels the additional testosterone exposure could be placing these men at higher risk of BPH. Overall, these data suggest that BPH may not have been an inevitable part of male aging throughout human evolutionary history.

Original languageEnglish (US)
Pages (from-to)1262-1268
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number10
DOIs
StatePublished - Nov 19 2014
Externally publishedYes

Fingerprint

Prostatic Hyperplasia
Prostate
Testosterone
Glycosylated Hemoglobin A
Sex Hormone-Binding Globulin
Prostate-Specific Antigen
Life Style
Obesity
Biomarkers
History

Keywords

  • Benign prostatic hyperplasia
  • Evolutionary medicine
  • Metabolic syndrome
  • Prostate specific antigen
  • Testosterone

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Challenging the Inevitability of Prostate Enlargement : Low Levels of Benign Prostatic Hyperplasia among Tsimane Forager-Horticulturalists. / Trumble, Benjamin; Stieglitz, Jonathan; Rodriguez, Daniel Eid; Linares, Edhitt Cortez; Kaplan, Hillard S.; Gurven, Michael D.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 70, No. 10, 19.11.2014, p. 1262-1268.

Research output: Contribution to journalArticle

Trumble, Benjamin ; Stieglitz, Jonathan ; Rodriguez, Daniel Eid ; Linares, Edhitt Cortez ; Kaplan, Hillard S. ; Gurven, Michael D. / Challenging the Inevitability of Prostate Enlargement : Low Levels of Benign Prostatic Hyperplasia among Tsimane Forager-Horticulturalists. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2014 ; Vol. 70, No. 10. pp. 1262-1268.
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