Challenges of detecting bioterrorism agents in complex matrices

Erica M. Hartmann, Rolf Halden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This chapter offers an overview of the shift from the use of mass-spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.

Original languageEnglish (US)
Title of host publicationDetection of Biological Agents for the Prevention of Bioterrorism
EditorsJoseph Banoub
Pages149-162
Number of pages14
DOIs
StatePublished - Jan 1 2011

Publication series

NameNATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)1874-6489

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Keywords

  • Environmental samples
  • clinical samples
  • norovirus
  • stool

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Safety, Risk, Reliability and Quality

Cite this

Hartmann, E. M., & Halden, R. (2011). Challenges of detecting bioterrorism agents in complex matrices. In J. Banoub (Ed.), Detection of Biological Agents for the Prevention of Bioterrorism (pp. 149-162). (NATO Science for Peace and Security Series A: Chemistry and Biology). https://doi.org/10.1007/978-90-481-9815-3-10