TY - JOUR
T1 - Challenges and opportunities for structural DNA nanotechnology
AU - Pinheiro, Andre V.
AU - Han, Dongran
AU - Shih, William M.
AU - Yan, Hao
N1 - Funding Information:
We thank K. Gothelf and T. LaBean for discussions. H.Y. acknowledges funding support from the Office of Naval Research (ONR), the Army Research office, the National Science Foundation, the National Institutes of Health (NIH), the Department of Energy, Sloan Research Fellowship and Arizona State University. W.M.S acknowledges funding support from ONR, NIH, Agilent Technologies and the Wyss Institute for Biologically Inspired Engineering. We also thank J. Nangreave for proofreading the manuscript.
PY - 2011/12
Y1 - 2011/12
N2 - DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
AB - DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
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U2 - 10.1038/nnano.2011.187
DO - 10.1038/nnano.2011.187
M3 - Review article
C2 - 22056726
AN - SCOPUS:83555174809
SN - 1748-3387
VL - 6
SP - 763
EP - 772
JO - Nature nanotechnology
JF - Nature nanotechnology
IS - 12
ER -