Abstract

DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.

Original languageEnglish (US)
Pages (from-to)763-772
Number of pages10
JournalNature Nanotechnology
Volume6
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

nanotechnology
Nanotechnology
DNA
deoxyribonucleic acid
Biophysics
biophysics
biomimetics
Biomimetics
Energy transfer
Photonics
Self assembly
health
self assembly
Nanostructures
energy transfer
Health
photonics
costs
Molecules
Costs

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Challenges and opportunities for structural DNA nanotechnology. / Pinheiro, Andre V.; Han, Dongran; Shih, William M.; Yan, Hao.

In: Nature Nanotechnology, Vol. 6, No. 12, 12.2011, p. 763-772.

Research output: Contribution to journalArticle

Pinheiro, Andre V. ; Han, Dongran ; Shih, William M. ; Yan, Hao. / Challenges and opportunities for structural DNA nanotechnology. In: Nature Nanotechnology. 2011 ; Vol. 6, No. 12. pp. 763-772.
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