Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer

João Siufi Neto, Rosanne M. Kho, Daniela Freitas dos Santos Siufi, Edmund Chada Baracat, Karen Anderson, Maurício Simões Abrão

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalJournal of Minimally Invasive Gynecology
Volume21
Issue number1
DOIs
StatePublished - Jan 2014

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Endometriosis
Ovarian Neoplasms
Lymphoid Tissue
MicroRNAs
Epigenomics
Genes
Neoplasms
Biomarkers
Carcinoma
Phenotype
Mutation

Keywords

  • Endometriosis
  • MicroRNA
  • Molecular alterations
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer. / Siufi Neto, João; Kho, Rosanne M.; dos Santos Siufi, Daniela Freitas; Baracat, Edmund Chada; Anderson, Karen; Abrão, Maurício Simões.

In: Journal of Minimally Invasive Gynecology, Vol. 21, No. 1, 01.2014, p. 55-63.

Research output: Contribution to journalArticle

Siufi Neto, João ; Kho, Rosanne M. ; dos Santos Siufi, Daniela Freitas ; Baracat, Edmund Chada ; Anderson, Karen ; Abrão, Maurício Simões. / Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer. In: Journal of Minimally Invasive Gynecology. 2014 ; Vol. 21, No. 1. pp. 55-63.
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