Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer

João Siufi Neto, Rosanne M. Kho, Daniela Freitas dos Santos Siufi, Edmund Chada Baracat, Karen Anderson, Maurício Simões Abrão

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalJournal of Minimally Invasive Gynecology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Endometriosis
  • MicroRNA
  • Molecular alterations
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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