Cellular functionality on nanotubes of Ti-30Ta alloy

Patricia Capellato, Barbara S. Smith, Ketul C. Popat, Ana P.R. Alves Claro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.

Original languageEnglish (US)
Title of host publicationA Special Issue in Memory of Dr. Lucio Salgado
EditorsLucio Salgado
PublisherTrans Tech Publications Ltd
Pages61-64
Number of pages4
ISBN (Electronic)9783038352365
DOIs
StatePublished - Jan 1 2015
Externally publishedYes
Event56 Brazilian Ceramic Conference, COLAOB 2012, Latin American Cong. of Artificial Organs and Biomaterials, 2012, 7th International Conference on Intelligent Processing and Manufacturing of Materials, IPMM, 2012, Brazilian Surface Treatments and Exhibition, EBRATS 2012, Ptech - 8th International Latin American Conference on Powder Technology, 2011 - Foz de Iguaçu, Brazil
Duration: Sep 2 2012Sep 3 2012

Publication series

NameMaterials Science Forum
Volume805
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Other

Other56 Brazilian Ceramic Conference, COLAOB 2012, Latin American Cong. of Artificial Organs and Biomaterials, 2012, 7th International Conference on Intelligent Processing and Manufacturing of Materials, IPMM, 2012, Brazilian Surface Treatments and Exhibition, EBRATS 2012, Ptech - 8th International Latin American Conference on Powder Technology, 2011
Country/TerritoryBrazil
CityFoz de Iguaçu
Period9/2/129/3/12

Keywords

  • Human dermal fibroblasts
  • Ti-30Ta nanotube arrays

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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