TY - GEN
T1 - Cellular functionality on nanotubes of Ti-30Ta alloy
AU - Capellato, Patricia
AU - Smith, Barbara S.
AU - Popat, Ketul C.
AU - Alves Claro, Ana P.R.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.
AB - Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.
KW - Human dermal fibroblasts
KW - Ti-30Ta nanotube arrays
UR - http://www.scopus.com/inward/record.url?scp=84922238460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922238460&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/MSF.805.61
DO - 10.4028/www.scientific.net/MSF.805.61
M3 - Conference contribution
AN - SCOPUS:84922238460
T3 - Materials Science Forum
SP - 61
EP - 64
BT - A Special Issue in Memory of Dr. Lucio Salgado
A2 - Salgado, Lucio
PB - Trans Tech Publications Ltd
T2 - 56 Brazilian Ceramic Conference, COLAOB 2012, Latin American Cong. of Artificial Organs and Biomaterials, 2012, 7th International Conference on Intelligent Processing and Manufacturing of Materials, IPMM, 2012, Brazilian Surface Treatments and Exhibition, EBRATS 2012, Ptech - 8th International Latin American Conference on Powder Technology, 2011
Y2 - 2 September 2012 through 3 September 2012
ER -