Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions

James E. Cox; William J. Tyler; Alan Randich; Gary R. Kelm; Stephen T. Meller

doi:10.1097/00001756-200105080-00009

Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions

James E. Cox, William J. Tyler, Alan Randich, Gary R. Kelm, Stephen T. Meller

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We investigated the role of the celiac branch of the vagus nerve in suppression of food intake produced by jejunal fatty acids infusions. Following selective celiac vagotomy or sham surgery, adult, male Sprague-Dawley rats received 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced significant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of results suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids.

Original language	English (US)
Pages (from-to)	1093-1096
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	6
DOIs	https://doi.org/10.1097/00001756-200105080-00009
State	Published - May 8 2001
Externally published	Yes

Keywords

Linoleic acid
Rats
Satiety
Small intestine
Vagal afferents

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-200105080-00009

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abstract = "We investigated the role of the celiac branch of the vagus nerve in suppression of food intake produced by jejunal fatty acids infusions. Following selective celiac vagotomy or sham surgery, adult, male Sprague-Dawley rats received 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced significant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of results suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids.",

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AU - Cox, James E.

AU - Tyler, William J.

AU - Randich, Alan

AU - Kelm, Gary R.

AU - Meller, Stephen T.

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AB - We investigated the role of the celiac branch of the vagus nerve in suppression of food intake produced by jejunal fatty acids infusions. Following selective celiac vagotomy or sham surgery, adult, male Sprague-Dawley rats received 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced significant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of results suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids.

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KW - Satiety

KW - Small intestine

KW - Vagal afferents

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Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions

Abstract

Keywords

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