Cease and desist

Modulating short-range Dpp signalling in the stem-cell niche

Robin Harris, Hilary L. Ashe

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To ensure the correct balance between stem-cell maintenance and differentiation, several regulatory mechanisms that modulate the Dpp signal at many stages of the pathway have been described. Here, we discuss the nature of the ovarian Dpp signal and review the catalogue of mechanisms that regulate it, demonstrating how the exquisite modulation of Dpp signalling in this context can result in precise and robust control of stem-cell fate. This modulation is applicable to other stem-cell environments that use BMPs as a niche signal, and the regulatory mechanisms are conceptually relevant to several other stem-cell systems.

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalEMBO Reports
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Fingerprint

Stem Cell Niche
Stem cells
Stem Cells
Modulation
Drosophila
Cell Differentiation
Maintenance
Robust control

Keywords

  • BMPp
  • Dpp
  • Drosophila
  • ovary
  • stem cells

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Cease and desist : Modulating short-range Dpp signalling in the stem-cell niche. / Harris, Robin; Ashe, Hilary L.

In: EMBO Reports, Vol. 12, No. 6, 01.06.2011, p. 519-526.

Research output: Contribution to journalReview article

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