CDC17

An essential gene that prevents telomere elongation in yeast

Michael J. Carson, Leland Hartwell

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The CDC17 gene product performs an essential stage-specific function during the Saccharomyces cerevisiae cell cycle. When cdc17-1 strains are grown at the maximum permissive temperature, recombination is induced preferentially in the genetic interval of the chromosome closest to the telomere. Telomeres are longer in cdc17 strains than in CDC17 strains at the permissive temperature because of addition of sequence near or in the poly (C1-3A) telomeric DNA and become even longer when cells are propagated at elevated temperatures. The mitotic recombination events require RAD52 function, but telomere growth does not. Long telomeres are maintained for many generations when crossed into a CDC17++ background, suggesting that telomere length is largely conserved during replication. The altered- telomere length phenotype of cdc17 mutations is recessive and coreverts and cosegregates with the temperature-sensitive lethal phenotype.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalCell
Volume42
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Essential Genes
Telomere
Yeast
Elongation
Genes
Yeasts
Temperature
Genetic Recombination
Chromosomes
Phenotype
Cells
Saccharomyces cerevisiae
DNA
Cell Cycle
Mutation
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Medicine(all)

Cite this

CDC17 : An essential gene that prevents telomere elongation in yeast. / Carson, Michael J.; Hartwell, Leland.

In: Cell, Vol. 42, No. 1, 1985, p. 249-257.

Research output: Contribution to journalArticle

Carson, Michael J. ; Hartwell, Leland. / CDC17 : An essential gene that prevents telomere elongation in yeast. In: Cell. 1985 ; Vol. 42, No. 1. pp. 249-257.
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