CD137 promotes proliferation and survival of human B cells

Xiaoyu Zhang; Caroline J. Voskens; Michelle Sallin; Amudhan Maniar; Carolina L. Montes; Yue Zhang; Wei Lin; Guoyan Li; Erin Burch; Ming Tan; Ronna Hertzano; Andrei I. Chapoval; Koji Tamada; Brian R. Gastman; Dan H. Schulze; Scott E. Strome

doi:10.4049/jimmunol.0901619

CD137 promotes proliferation and survival of human B cells

Xiaoyu Zhang, Caroline J. Voskens, Michelle Sallin, Amudhan Maniar, Carolina L. Montes, Yue Zhang, Wei Lin, Guoyan Li, Erin Burch, Ming Tan, Ronna Hertzano, Andrei I. Chapoval, Koji Tamada, Brian R. Gastman, Dan H. Schulze, Scott E. Strome

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown.We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-γ and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-α and -β. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.

Original language	English (US)
Pages (from-to)	787-795
Number of pages	9
Journal	Journal of Immunology
Volume	184
Issue number	2
DOIs	https://doi.org/10.4049/jimmunol.0901619
State	Published - Jan 15 2010
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "CD137 promotes proliferation and survival of human B cells",

abstract = "CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown.We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-γ and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-α and -β. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.",

author = "Xiaoyu Zhang and Voskens, {Caroline J.} and Michelle Sallin and Amudhan Maniar and Montes, {Carolina L.} and Yue Zhang and Wei Lin and Guoyan Li and Erin Burch and Ming Tan and Ronna Hertzano and Chapoval, {Andrei I.} and Koji Tamada and Gastman, {Brian R.} and Schulze, {Dan H.} and Strome, {Scott E.}",

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doi = "10.4049/jimmunol.0901619",

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T1 - CD137 promotes proliferation and survival of human B cells

AU - Zhang, Xiaoyu

AU - Voskens, Caroline J.

AU - Sallin, Michelle

AU - Maniar, Amudhan

AU - Montes, Carolina L.

AU - Zhang, Yue

AU - Lin, Wei

AU - Li, Guoyan

AU - Burch, Erin

AU - Tan, Ming

AU - Hertzano, Ronna

AU - Chapoval, Andrei I.

AU - Tamada, Koji

AU - Gastman, Brian R.

AU - Schulze, Dan H.

AU - Strome, Scott E.

PY - 2010/1/15

Y1 - 2010/1/15

N2 - CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown.We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-γ and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-α and -β. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.

AB - CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown.We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-γ and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-α and -β. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.

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CD137 promotes proliferation and survival of human B cells

Abstract

ASJC Scopus subject areas

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