CD137 promotes proliferation and survival of human B cells

Xiaoyu Zhang, Caroline J. Voskens, Michelle Sallin, Amudhan Maniar, Carolina L. Montes, Yue Zhang, Wei Lin, Guoyan Li, Erin Burch, Ming Tan, Ronna Hertzano, Andrei I. Chapoval, Koji Tamada, Brian R. Gastman, Dan H. Schulze, Scott E. Strome

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown.We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-γ and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-α and -β. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.

Original languageEnglish (US)
Pages (from-to)787-795
Number of pages9
JournalJournal of Immunology
Volume184
Issue number2
DOIs
StatePublished - Jan 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Zhang, X., Voskens, C. J., Sallin, M., Maniar, A., Montes, C. L., Zhang, Y., Lin, W., Li, G., Burch, E., Tan, M., Hertzano, R., Chapoval, A. I., Tamada, K., Gastman, B. R., Schulze, D. H., & Strome, S. E. (2010). CD137 promotes proliferation and survival of human B cells. Journal of Immunology, 184(2), 787-795. https://doi.org/10.4049/jimmunol.0901619