Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

Matthew Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, Millicent O. Sullivan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

Original languageEnglish (US)
Pages (from-to)5535-5541
Number of pages7
JournalPolymer Chemistry
Volume5
Issue number19
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Nucleic acids
Nucleic Acids
Block copolymers
DNA
Product Packaging
Transcription
Complexation
Polyethylene glycols
Packaging
Genes
Light
Degradation

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Biochemistry
  • Biomedical Engineering
  • Bioengineering

Cite this

Green, M., Foster, A. A., Greco, C. T., Roy, R., Lehr, R. M., Epps, T. H., & Sullivan, M. O. (2014). Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery. Polymer Chemistry, 5(19), 5535-5541. https://doi.org/10.1039/c4py00638k

Catch and release : Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery. / Green, Matthew; Foster, Abbygail A.; Greco, Chad T.; Roy, Raghunath; Lehr, Rachel M.; Epps, Thomas H.; Sullivan, Millicent O.

In: Polymer Chemistry, Vol. 5, No. 19, 2014, p. 5535-5541.

Research output: Contribution to journalArticle

Green, Matthew ; Foster, Abbygail A. ; Greco, Chad T. ; Roy, Raghunath ; Lehr, Rachel M. ; Epps, Thomas H. ; Sullivan, Millicent O. / Catch and release : Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery. In: Polymer Chemistry. 2014 ; Vol. 5, No. 19. pp. 5535-5541.
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