Catch and release: Photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, Millicent O. Sullivan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

Original languageEnglish (US)
Pages (from-to)5535-5541
Number of pages7
JournalPolymer Chemistry
Volume5
Issue number19
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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