Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype

Michael D. Wirth, James B. Burch, James R. Hébert, Pradnya Kowtal, Aparna Mehrotra-Kapoor, Susan E. Steck, Thomas G. Hurley, Prakash C. Gupta, Mangesh S. Pednekar, Shawn D. Youngstedt, Hongmei Zhang, Rajiv Sarin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. Methods: This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010-2012. Results: Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype. Conclusions: Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalCancer Investigation
Volume32
Issue number7
DOIs
StatePublished - Aug 2014

Keywords

  • Breast Cancer
  • Circadian
  • Clock Gene
  • Diurnal Preference

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype'. Together they form a unique fingerprint.

  • Cite this

    Wirth, M. D., Burch, J. B., Hébert, J. R., Kowtal, P., Mehrotra-Kapoor, A., Steck, S. E., Hurley, T. G., Gupta, P. C., Pednekar, M. S., Youngstedt, S. D., Zhang, H., & Sarin, R. (2014). Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype. Cancer Investigation, 32(7), 321-329. https://doi.org/10.3109/07357907.2014.919305