Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype

Michael D. Wirth, James B. Burch, James R. Hébert, Pradnya Kowtal, Aparna Mehrotra-Kapoor, Susan E. Steck, Thomas G. Hurley, Prakash C. Gupta, Mangesh S. Pednekar, Shawn Youngstedt, Hongmei Zhang, Rajiv Sarin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. Methods: This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010-2012. Results: Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype. Conclusions: Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalCancer Investigation
Volume32
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Case-Control Studies
India
Breast Neoplasms
Minisatellite Repeats
Genes
Genotype

Keywords

  • Breast Cancer
  • Circadian
  • Clock Gene
  • Diurnal Preference

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wirth, M. D., Burch, J. B., Hébert, J. R., Kowtal, P., Mehrotra-Kapoor, A., Steck, S. E., ... Sarin, R. (2014). Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype. Cancer Investigation, 32(7), 321-329. https://doi.org/10.3109/07357907.2014.919305

Case-control study of breast cancer in India : Role of PERIOD3 clock gene length polymorphism and chronotype. / Wirth, Michael D.; Burch, James B.; Hébert, James R.; Kowtal, Pradnya; Mehrotra-Kapoor, Aparna; Steck, Susan E.; Hurley, Thomas G.; Gupta, Prakash C.; Pednekar, Mangesh S.; Youngstedt, Shawn; Zhang, Hongmei; Sarin, Rajiv.

In: Cancer Investigation, Vol. 32, No. 7, 2014, p. 321-329.

Research output: Contribution to journalArticle

Wirth, MD, Burch, JB, Hébert, JR, Kowtal, P, Mehrotra-Kapoor, A, Steck, SE, Hurley, TG, Gupta, PC, Pednekar, MS, Youngstedt, S, Zhang, H & Sarin, R 2014, 'Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype', Cancer Investigation, vol. 32, no. 7, pp. 321-329. https://doi.org/10.3109/07357907.2014.919305
Wirth, Michael D. ; Burch, James B. ; Hébert, James R. ; Kowtal, Pradnya ; Mehrotra-Kapoor, Aparna ; Steck, Susan E. ; Hurley, Thomas G. ; Gupta, Prakash C. ; Pednekar, Mangesh S. ; Youngstedt, Shawn ; Zhang, Hongmei ; Sarin, Rajiv. / Case-control study of breast cancer in India : Role of PERIOD3 clock gene length polymorphism and chronotype. In: Cancer Investigation. 2014 ; Vol. 32, No. 7. pp. 321-329.
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