@article{67074dad30a44d1481dec4a5fefd3dba,
title = "Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype",
abstract = "Background: This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. Methods: This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010-2012. Results: Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype. Conclusions: Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.",
keywords = "Breast Cancer, Circadian, Clock Gene, Diurnal Preference",
author = "Wirth, {Michael D.} and Burch, {James B.} and H{\'e}bert, {James R.} and Pradnya Kowtal and Aparna Mehrotra-Kapoor and Steck, {Susan E.} and Hurley, {Thomas G.} and Gupta, {Prakash C.} and Pednekar, {Mangesh S.} and Youngstedt, {Shawn D.} and Hongmei Zhang and Rajiv Sarin",
note = "Funding Information: The authors gratefully acknowledge the management and staff of Tata Memorial Hospital and Advanced Centre for Treatment, Research and Education in Cancer (Mumbai, India) where subject recruitment, data collection, biospec-imen processing, genotyping, database compilation, and preliminary analyses were performed. Data management and dietary questionnaire processing was performed at the Healis-Sekhsaria Institute for Public Health (Mumbai, India). Additional data processing and statistical analyses were performed at the University of South Carolina Cancer Prevention and Control Program (Columbia, SC, USA). Professor Simon Folkard (University of Wales Swansea, Wales, UK) provided access to questions from the Standard Shiftwork Index. This work was supported by a Research Opportunity Program grant from the University of South Carolina Office of Research and Economic Development; the Indian Council for Medical Research Grant; University of South Carolina{\textquoteright}s Behavioral-Biomedical Interface Program through the National Institute of General Medical Sciences at the National Institutes of Health [T32–5R18CE001240 to M.W.]; and an Established Investigator Award in Cancer Prevention and Control from the Cancer Training Branch of the National Cancer Institute at the National Institutes of Health [K05 CA136975 to J.R.H.].",
year = "2014",
month = aug,
doi = "10.3109/07357907.2014.919305",
language = "English (US)",
volume = "32",
pages = "321--329",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "7",
}