CAROTENOHEMATOPORPHYRIN ACIDS AS TUMOR LOCALIZING AND VISUALIZING AGENTS

Ana Moore (Inventor), Thomas Moore (Inventor)

Research output: Patent

Abstract

A new class of molecules consisting of two carotenoid polyenes covalently linked to free-carboxylic-acid-containing derivatives of naturally occurring heme (exemplified by structure1) have been synthesized for use as tumor localizing, visualizing and diagnostic agents. These carotenohematoporphyrin acids are designed to be administered by injection or other means, to localize preferentially in neoplastic tumor tissue, to absorb visible light and thereupon to fluoresce red light that can be detected by eye or by instrumental methods, thus identifying and delineating the tumor tissue. Furthermore, these compounds are designed to quench porphyrin triplet states by triplet tripletenergy transfer to an attached carotenoid. This will prevent formation of singlet oxygen by energy transfer from porphyrin triplet states, and thus prevent tissue damage to healthy tissue caused by the singlet oxygen.
Original languageEnglish (US)
StatePublished - Jan 1 1900

Fingerprint

Tumors
Tissue
Singlet Oxygen
Acids
Porphyrins
Carotenoids
Polyenes
Carboxylic Acids
Heme
Energy transfer
Derivatives
Molecules

Cite this

@misc{a0139403297e41e09f6753585851cb30,
title = "CAROTENOHEMATOPORPHYRIN ACIDS AS TUMOR LOCALIZING AND VISUALIZING AGENTS",
abstract = "A new class of molecules consisting of two carotenoid polyenes covalently linked to free-carboxylic-acid-containing derivatives of naturally occurring heme (exemplified by structure1) have been synthesized for use as tumor localizing, visualizing and diagnostic agents. These carotenohematoporphyrin acids are designed to be administered by injection or other means, to localize preferentially in neoplastic tumor tissue, to absorb visible light and thereupon to fluoresce red light that can be detected by eye or by instrumental methods, thus identifying and delineating the tumor tissue. Furthermore, these compounds are designed to quench porphyrin triplet states by triplet tripletenergy transfer to an attached carotenoid. This will prevent formation of singlet oxygen by energy transfer from porphyrin triplet states, and thus prevent tissue damage to healthy tissue caused by the singlet oxygen.",
author = "Ana Moore and Thomas Moore",
year = "1900",
month = "1",
day = "1",
language = "English (US)",
type = "Patent",

}

TY - PAT

T1 - CAROTENOHEMATOPORPHYRIN ACIDS AS TUMOR LOCALIZING AND VISUALIZING AGENTS

AU - Moore, Ana

AU - Moore, Thomas

PY - 1900/1/1

Y1 - 1900/1/1

N2 - A new class of molecules consisting of two carotenoid polyenes covalently linked to free-carboxylic-acid-containing derivatives of naturally occurring heme (exemplified by structure1) have been synthesized for use as tumor localizing, visualizing and diagnostic agents. These carotenohematoporphyrin acids are designed to be administered by injection or other means, to localize preferentially in neoplastic tumor tissue, to absorb visible light and thereupon to fluoresce red light that can be detected by eye or by instrumental methods, thus identifying and delineating the tumor tissue. Furthermore, these compounds are designed to quench porphyrin triplet states by triplet tripletenergy transfer to an attached carotenoid. This will prevent formation of singlet oxygen by energy transfer from porphyrin triplet states, and thus prevent tissue damage to healthy tissue caused by the singlet oxygen.

AB - A new class of molecules consisting of two carotenoid polyenes covalently linked to free-carboxylic-acid-containing derivatives of naturally occurring heme (exemplified by structure1) have been synthesized for use as tumor localizing, visualizing and diagnostic agents. These carotenohematoporphyrin acids are designed to be administered by injection or other means, to localize preferentially in neoplastic tumor tissue, to absorb visible light and thereupon to fluoresce red light that can be detected by eye or by instrumental methods, thus identifying and delineating the tumor tissue. Furthermore, these compounds are designed to quench porphyrin triplet states by triplet tripletenergy transfer to an attached carotenoid. This will prevent formation of singlet oxygen by energy transfer from porphyrin triplet states, and thus prevent tissue damage to healthy tissue caused by the singlet oxygen.

M3 - Patent

ER -