TY - JOUR
T1 - Cardiolipin signaling mechanisms
T2 - Collapse of asymmetry and oxidation
AU - Kagan, Valerian E.
AU - Tyurina, Yulia Y.
AU - Tyurin, Vladimir A.
AU - Mohammadyani, Dariush
AU - Angeli, Jose Pedro Friedmann
AU - Baranov, Sergei V.
AU - Klein-Seetharaman, Judith
AU - Friedlander, Robert M.
AU - Mallampalli, Rama K.
AU - Conrad, Marcus
AU - Bayir, Hülya
N1 - Publisher Copyright:
© Copyright 2015, Mary Ann Liebert, Inc. 2015.
PY - 2015/6/20
Y1 - 2015/6/20
N2 - Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and functional purposes. Recent Advances: The emerging role of CLs in signaling has become the focus of many studies. Critical Issues: In this work, we describe two major pathways through which mitochondrial CLs may fulfill the signaling functions via utilization of their (i) asymmetric distribution across membranes and translocations, leading to the surface externalization and (ii) ability to undergo oxidation reactions to yield the signature products recognizable by the executionary machinery of cells. Future Directions: We present a concept that CLs and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions. Antioxid. Redox Signal. 22, 1667-1680.
AB - Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and functional purposes. Recent Advances: The emerging role of CLs in signaling has become the focus of many studies. Critical Issues: In this work, we describe two major pathways through which mitochondrial CLs may fulfill the signaling functions via utilization of their (i) asymmetric distribution across membranes and translocations, leading to the surface externalization and (ii) ability to undergo oxidation reactions to yield the signature products recognizable by the executionary machinery of cells. Future Directions: We present a concept that CLs and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions. Antioxid. Redox Signal. 22, 1667-1680.
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U2 - 10.1089/ars.2014.6219
DO - 10.1089/ars.2014.6219
M3 - Review article
C2 - 25566681
AN - SCOPUS:84930617981
SN - 1523-0864
VL - 22
SP - 1667
EP - 1680
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 18
ER -