Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

Craig A. Poland, Rodger Duffin, Ian Kinloch, Andrew Maynard, William A H Wallace, Anthony Seaton, Vicki Stone, Simon Brown, William MacNee, Ken Donaldson

Research output: Contribution to journalArticle

1865 Citations (Scopus)

Abstract

Carbon nanotubes have distinctive characteristics, but their needle-like fibre shape has been compared to asbestos, raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos. Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest cavity, to long multiwalled carbon nanotubes results in asbestos-like, length-dependent, pathogenic behaviour. This includes inflammation and the formation of lesions known as granulomas. This is of considerable importance, because research and business communities continue to invest heavily in carbon nanotubes for a wide range of products under the assumption that they are no more hazardous than graphite. Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalNature Nanotechnology
Volume3
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

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asbestos
Carbon Nanotubes
Asbestos
Linings
mice
Carbon nanotubes
linings
carbon nanotubes
cavities
Graphite
Multiwalled carbon nanotubes (MWCN)
Needles
chest
products
needles
lungs
lesions
Fibers
graphite
cancer

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. / Poland, Craig A.; Duffin, Rodger; Kinloch, Ian; Maynard, Andrew; Wallace, William A H; Seaton, Anthony; Stone, Vicki; Brown, Simon; MacNee, William; Donaldson, Ken.

In: Nature Nanotechnology, Vol. 3, No. 7, 07.2008, p. 423-428.

Research output: Contribution to journalArticle

Poland, CA, Duffin, R, Kinloch, I, Maynard, A, Wallace, WAH, Seaton, A, Stone, V, Brown, S, MacNee, W & Donaldson, K 2008, 'Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study', Nature Nanotechnology, vol. 3, no. 7, pp. 423-428. https://doi.org/10.1038/nnano.2008.111
Poland, Craig A. ; Duffin, Rodger ; Kinloch, Ian ; Maynard, Andrew ; Wallace, William A H ; Seaton, Anthony ; Stone, Vicki ; Brown, Simon ; MacNee, William ; Donaldson, Ken. / Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. In: Nature Nanotechnology. 2008 ; Vol. 3, No. 7. pp. 423-428.
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