Cancer initiation and progression within the cancer microenvironment

Stanley P. Leong, C Athena Aktipis, Carlo Maley

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Within the cancer microenvironment, the growth and proliferation of cancer cells in the primary site as well as in the metastatic site represent a global biological phenomenon. To understand the growth, proliferation and progression of cancer either by local expansion and/or metastasis, it is important to understand the cancer microenvironment and host response to cancer growth. Melanoma is an excellent model to study the interaction of cancer initiation and growth in relationship to its microenvironment. Social evolution with cooperative cellular groups within an organism is what gives rise to multicellularity in the first place. Cancer cells evolve to exploit their cellular environment. The foundations of multicellular cooperation break down in cancer because those cells that misbehave have an evolutionary advantage over their normally behaving neighbors. It is important to classify evolutionary and ecological aspects of cancer growth, thus, data for cancer growth and outcomes need to be collected to define these parameters so that accurate predictions of how cancer cells may proliferate and metastasize can be developed.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalClinical and Experimental Metastasis
DOIs
StateAccepted/In press - Jul 11 2018

Fingerprint

Tumor Microenvironment
Neoplasms
Growth
Biological Phenomena
Melanoma
Cell Proliferation
Neoplasm Metastasis

Keywords

  • Cancer ecology
  • Cancer evolution
  • Cancer microenvironment
  • Natural selection

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cancer initiation and progression within the cancer microenvironment. / Leong, Stanley P.; Aktipis, C Athena; Maley, Carlo.

In: Clinical and Experimental Metastasis, 11.07.2018, p. 1-7.

Research output: Contribution to journalArticle

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