Cancer in light of experimental evolution

Kathleen Sprouffske, Lauren M F Merlo, Philip J. Gerrish, Carlo Maley, Paul D. Sniegowski

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary phenomena of clonal somatic cell populations. Studies in microbial experimental evolution and the theoretical work inspired by such studies are yielding deep insights into the evolutionary dynamics of clonal populations, yet there has been little explicit consideration of the relevance of this rapidly growing field to cancer biology. Here, we examine how the understanding of mutation, selection, and spatial structure in clonal populations that is emerging from experimental evolution may be applicable to cancer. Along the way, we discuss some significant ways in which cancer differs from the model systems used in experimental evolution. Despite these differences, we argue that enhanced prediction and control of cancer may be possible using ideas developed in the context of experimental evolution, and we point out some prospects for future research at the interface between these traditionally separate areas.

Original languageEnglish (US)
JournalCurrent Biology
Volume22
Issue number17
DOIs
StatePublished - Sep 11 2012
Externally publishedYes

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Cells
neoplasms
Neoplasms
Population Dynamics
somatic cells
Population
mutation
Biological Sciences
therapeutics
Mutation
prediction
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sprouffske, K., Merlo, L. M. F., Gerrish, P. J., Maley, C., & Sniegowski, P. D. (2012). Cancer in light of experimental evolution. Current Biology, 22(17). https://doi.org/10.1016/j.cub.2012.06.065

Cancer in light of experimental evolution. / Sprouffske, Kathleen; Merlo, Lauren M F; Gerrish, Philip J.; Maley, Carlo; Sniegowski, Paul D.

In: Current Biology, Vol. 22, No. 17, 11.09.2012.

Research output: Contribution to journalArticle

Sprouffske, K, Merlo, LMF, Gerrish, PJ, Maley, C & Sniegowski, PD 2012, 'Cancer in light of experimental evolution', Current Biology, vol. 22, no. 17. https://doi.org/10.1016/j.cub.2012.06.065
Sprouffske K, Merlo LMF, Gerrish PJ, Maley C, Sniegowski PD. Cancer in light of experimental evolution. Current Biology. 2012 Sep 11;22(17). https://doi.org/10.1016/j.cub.2012.06.065
Sprouffske, Kathleen ; Merlo, Lauren M F ; Gerrish, Philip J. ; Maley, Carlo ; Sniegowski, Paul D. / Cancer in light of experimental evolution. In: Current Biology. 2012 ; Vol. 22, No. 17.
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