Cancer as an evolutionary and ecological process

Lauren M.F. Merlo, John W. Pepper, Brian J. Reid, Carlo C. Maley

Research output: Contribution to journalReview articlepeer-review

1024 Scopus citations

Abstract

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.

Original languageEnglish (US)
Pages (from-to)924-935
Number of pages12
JournalNature Reviews Cancer
Volume6
Issue number12
DOIs
StatePublished - Dec 9 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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