Cancer as a dynamical phase transition

Paul Davies, Lloyd Demetrius, Jack A. Tuszynski

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

This paper discusses the properties of cancer cells from a new perspective based on an analogy with phase transitions in physical systems. Similarities in terms of instabilities and attractor states are outlined and differences discussed. While physical phase transitions typically occur at or near thermodynamic equilibrium, a normal-to-cancer (NTC) transition is a dynamical non-equilibrium phenomenon, which depends on both metabolic energy supply and local physiological conditions. A number of implications for preventative and therapeutic strategies are outlined.

Original languageEnglish (US)
Article number30
JournalTheoretical Biology and Medical Modelling
Volume8
Issue number1
DOIs
StatePublished - 2011

Fingerprint

Dynamical Phase Transition
Phase Transition
Cancer
Phase transitions
Thermodynamic Equilibrium
Thermodynamics
Non-equilibrium
Analogy
Attractor
Neoplasms
Cells
Cell
Energy
Therapeutics
Similarity
Strategy

ASJC Scopus subject areas

  • Health Informatics
  • Modeling and Simulation

Cite this

Cancer as a dynamical phase transition. / Davies, Paul; Demetrius, Lloyd; Tuszynski, Jack A.

In: Theoretical Biology and Medical Modelling, Vol. 8, No. 1, 30, 2011.

Research output: Contribution to journalArticle

Davies, Paul ; Demetrius, Lloyd ; Tuszynski, Jack A. / Cancer as a dynamical phase transition. In: Theoretical Biology and Medical Modelling. 2011 ; Vol. 8, No. 1.
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