Calcium signals in neutrophils can be divided into three distinct phases

Douglas E. Chandler, Charles J. Kazilek

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Rabbit neutrophils were loaded with the fluorescence probe indo-1 and cytosolic free calcium levels were monitored during chemotactic peptide (fMet-Leu-Phe) stimulation. The fMet-Leu-Phe-induced calcium signal consisted of three consecutive phases: (1) an initial peak that was independent of extracellular calcium, (2) a secondary shoulder that required extracellular calcium but was totally blocked by hyperosmolality and (3) a final plateau of elevated calcium that was dependent on extracellular calcium but insensitive to hyperosmolality.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBBA - Molecular Cell Research
Volume931
Issue number2
DOIs
StatePublished - Nov 12 1987

Keywords

  • (Neutrophil)
  • Calcium signal
  • Chemotactic peptide
  • Hyperosmolality
  • Lysosomal enzyme release

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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