Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage

Karen Bulloch, Antara Prasad, Cheryl D. Conrad, Bruce S. McEwen, Teresa A. Milner

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Calcitonin gene related peptide-like immunoreactivity (CGRP-LI) was examined in rat dentate gyrus (DG) following damage to granule cells by adrenalectomy or intrahippocampal colchicine injections. In normal DG, CGRP- LI was present in a diffuse band within the inner third of the molecular layer (ITML) and in hilar cells. Following the experimental procedures, levels of CGRP-LI increased bilaterally in the ITML and in hilar interneurons resembling mossy cells. Ultrastructural analysis of the ITML revealed that CGRP-LI is associated with large, dense-core vesicles within axon terminals which form asymmetrical synapses with dendritic spines, and within dendritic spines. The increase in CGRP-LI level following granule cell damage suggests a protective role for CGRP in the response to hippocampal injury.

Original languageEnglish (US)
Pages (from-to)1036-1040
Number of pages5
JournalNeuroReport
Volume7
Issue number5
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • CGRP
  • dentate gyrus damage
  • hippocampus
  • molecular layer
  • mossy cells

ASJC Scopus subject areas

  • Neuroscience(all)

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