Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage

Karen Bulloch, Antara Prasad, Cheryl Conrad, Bruce S. McEwen, Teresa A. Milner

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Calcitonin gene related peptide-like immunoreactivity (CGRP-LI) was examined in rat dentate gyrus (DG) following damage to granule cells by adrenalectomy or intrahippocampal colchicine injections. In normal DG, CGRP- LI was present in a diffuse band within the inner third of the molecular layer (ITML) and in hilar cells. Following the experimental procedures, levels of CGRP-LI increased bilaterally in the ITML and in hilar interneurons resembling mossy cells. Ultrastructural analysis of the ITML revealed that CGRP-LI is associated with large, dense-core vesicles within axon terminals which form asymmetrical synapses with dendritic spines, and within dendritic spines. The increase in CGRP-LI level following granule cell damage suggests a protective role for CGRP in the response to hippocampal injury.

Original languageEnglish (US)
Pages (from-to)1036-1040
Number of pages5
JournalNeuroReport
Volume7
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Calcitonin Gene-Related Peptide
Dentate Gyrus
Dendritic Spines
Adrenalectomy
Presynaptic Terminals
Secretory Vesicles
Colchicine
Interneurons
Synapses
Injections
Wounds and Injuries

Keywords

  • CGRP
  • dentate gyrus damage
  • hippocampus
  • molecular layer
  • mossy cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bulloch, K., Prasad, A., Conrad, C., McEwen, B. S., & Milner, T. A. (1996). Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage. NeuroReport, 7(5), 1036-1040.

Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage. / Bulloch, Karen; Prasad, Antara; Conrad, Cheryl; McEwen, Bruce S.; Milner, Teresa A.

In: NeuroReport, Vol. 7, No. 5, 1996, p. 1036-1040.

Research output: Contribution to journalArticle

Bulloch, K, Prasad, A, Conrad, C, McEwen, BS & Milner, TA 1996, 'Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage', NeuroReport, vol. 7, no. 5, pp. 1036-1040.
Bulloch, Karen ; Prasad, Antara ; Conrad, Cheryl ; McEwen, Bruce S. ; Milner, Teresa A. / Calcitonin gene-related peptide level in the rat dentate gyrus increases after damage. In: NeuroReport. 1996 ; Vol. 7, No. 5. pp. 1036-1040.
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