Abstract
Calcitonin gene related peptide-like immunoreactivity (CGRP-LI) was examined in rat dentate gyrus (DG) following damage to granule cells by adrenalectomy or intrahippocampal colchicine injections. In normal DG, CGRP- LI was present in a diffuse band within the inner third of the molecular layer (ITML) and in hilar cells. Following the experimental procedures, levels of CGRP-LI increased bilaterally in the ITML and in hilar interneurons resembling mossy cells. Ultrastructural analysis of the ITML revealed that CGRP-LI is associated with large, dense-core vesicles within axon terminals which form asymmetrical synapses with dendritic spines, and within dendritic spines. The increase in CGRP-LI level following granule cell damage suggests a protective role for CGRP in the response to hippocampal injury.
Original language | English (US) |
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Pages (from-to) | 1036-1040 |
Number of pages | 5 |
Journal | NeuroReport |
Volume | 7 |
Issue number | 5 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- CGRP
- dentate gyrus damage
- hippocampus
- molecular layer
- mossy cells
ASJC Scopus subject areas
- General Neuroscience