Butyrate-inducible and tumor-restricted gene expression by adenovirus vectors.

D. C. Tang, S. A. Johnston, D. P. Carbone

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Efficient introduction of biologically active genes into tumor cells in vivo would facilitate cancer gene therapy. In this study, recombinant adenoviruses mediated high-level expression of reporter genes in both human and murine tumor cell lines and freshly resected human solid tumors in vitro. When adenovirus vectors were inoculated intratumorally in a living animal, reporter activity was detected only in the tumor nodule and not in other sites, in contrast to intracardiac injections in which expression was found in several organs. Adenovirus-mediated gene expression was further enhanced by butyrate treatment.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalCancer gene therapy
Volume1
Issue number1
StatePublished - Mar 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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