Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

Yoshiaki Kamano; Hiroshi Morita; Rui Takano; Ayano Kotake; Toshihiko Nogawa; Hirohumi Hashima; Koichi Takeya; Hideji Itokawa; George Pettit

doi:10.3987/COM-98-S(H)55

Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

Yoshiaki Kamano, Hiroshi Morita, Rui Takano, Ayano Kotake, Toshihiko Nogawa, Hirohumi Hashima, Koichi Takeya, Hideji Itokawa, George Pettit

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Two new bioactive indole alkaloids, 5-hydroxytryptamine (serotonin) N-4- oxobutanoic acid and 5-hydroxytryptamine N-acetyl-N-pyrrolecarboxamide, named as bufobutanoic acid (2) and bufopyramide (3), respectively, were isolated from the Chinese traditional drug Ch'an Su in addition to known bufotenine (1). The structures were elucidated on the basis of spectroscopic data. Bufobutanoic acid (2) and bufopyramide (3) exhibited cytotoxicity against murine P388 lymphocytic leukemia cells with IC₅₀ values of 22 μg/mL and 7.6 μg/mL, respectively.

Original language	English (US)
Pages (from-to)	499-503
Number of pages	5
Journal	Heterocycles
Volume	50
Issue number	1
DOIs	https://doi.org/10.3987/COM-98-S(H)55
State	Published - Jan 1 1999

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Two new bioactive indole alkaloids, 5-hydroxytryptamine (serotonin) N-4- oxobutanoic acid and 5-hydroxytryptamine N-acetyl-N-pyrrolecarboxamide, named as bufobutanoic acid (2) and bufopyramide (3), respectively, were isolated from the Chinese traditional drug Ch'an Su in addition to known bufotenine (1). The structures were elucidated on the basis of spectroscopic data. Bufobutanoic acid (2) and bufopyramide (3) exhibited cytotoxicity against murine P388 lymphocytic leukemia cells with IC50 values of 22 μg/mL and 7.6 μg/mL, respectively.",

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T1 - Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

AU - Kamano, Yoshiaki

AU - Morita, Hiroshi

AU - Takano, Rui

AU - Kotake, Ayano

AU - Nogawa, Toshihiko

AU - Hashima, Hirohumi

AU - Takeya, Koichi

AU - Itokawa, Hideji

AU - Pettit, George

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Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

Abstract

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