Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su

Yoshiaki Kamano, Hiroshi Morita, Rui Takano, Ayano Kotake, Toshihiko Nogawa, Hirohumi Hashima, Koichi Takeya, Hideji Itokawa, George Pettit

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Two new bioactive indole alkaloids, 5-hydroxytryptamine (serotonin) N-4- oxobutanoic acid and 5-hydroxytryptamine N-acetyl-N-pyrrolecarboxamide, named as bufobutanoic acid (2) and bufopyramide (3), respectively, were isolated from the Chinese traditional drug Ch'an Su in addition to known bufotenine (1). The structures were elucidated on the basis of spectroscopic data. Bufobutanoic acid (2) and bufopyramide (3) exhibited cytotoxicity against murine P388 lymphocytic leukemia cells with IC50 values of 22 μg/mL and 7.6 μg/mL, respectively.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalHeterocycles
Volume50
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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    Kamano, Y., Morita, H., Takano, R., Kotake, A., Nogawa, T., Hashima, H., Takeya, K., Itokawa, H., & Pettit, G. (1999). Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su. Heterocycles, 50(1), 499-503. https://doi.org/10.3987/COM-98-S(H)55