Bufadienolides. 28. Marinobufotoxin

George Pettit, Yoshiaki Kamano

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Syntheses of marinobufagin (5b) and marinobufotoxin (5e) have been achieved. The principal synthetic transformations involved selective dehydration of telocinobufagin (2) and addition of hypohalpus acid to the resulting olefin (2 → 3 →4) followed by dehydrohalogenation to yield marinobufagin (5b). Application of a carefully developed mixed carbonic anhydride reaction to the condensation of marinobufagin suberate (5c) with arginine monohydrochloride provided marinobufotoxin (5e).

Original languageEnglish (US)
Pages (from-to)3003-3006
Number of pages4
JournalJournal of Organic Chemistry
Volume39
Issue number20
DOIs
StatePublished - Oct 1 1974

ASJC Scopus subject areas

  • Organic Chemistry

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