Bufadienolides. 28. Marinobufotoxin

George Pettit, Yoshiaki Kamano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Syntheses of marinobufagin (5b) and marinobufotoxin (5e) have been achieved. The principal synthetic transformations involved selective dehydration of telocinobufagin (2) and addition of hypohalous acid to the resulting olefin (2 → 3 → 4) followed by dehydrohalogenation to yield marinobufagin (5b). Application of a carefully developed mixed carbonic anhydride reaction to the condensation of marinobufagin suberate (5c) with arginine monohydrochloride provided marinobufotoxin (5e).

Original languageEnglish (US)
Pages (from-to)3003-3006
Number of pages4
JournalJournal of Organic Chemistry
Volume39
Issue number20
StatePublished - 1974

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Bufanolides
Alkenes
Dehydration
Carbon Dioxide
Arginine
Condensation
Acids
marinobufotoxin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Bufadienolides. 28. Marinobufotoxin. / Pettit, George; Kamano, Yoshiaki.

In: Journal of Organic Chemistry, Vol. 39, No. 20, 1974, p. 3003-3006.

Research output: Contribution to journalArticle

Pettit, G & Kamano, Y 1974, 'Bufadienolides. 28. Marinobufotoxin', Journal of Organic Chemistry, vol. 39, no. 20, pp. 3003-3006.
Pettit, George ; Kamano, Yoshiaki. / Bufadienolides. 28. Marinobufotoxin. In: Journal of Organic Chemistry. 1974 ; Vol. 39, No. 20. pp. 3003-3006.
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