Bufadienolides. 26. Synthesis of Scillarenin

Yoshiaki Kamano; George Pettit

doi:10.1021/jo00931a041

Bufadienolides. 26. Synthesis of Scillarenin

Yoshiaki Kamano, George Pettit

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16 Scopus citations

Abstract

Bufalin (1), previously synthesized from digitoxigenin, was utilized as relay in a new synthetic route to scillarenin (4). Important steps in the synthesis of scillarenin included bromination and dehydrohalogenation of bufalone (2a) to yield scillarenone (3). The overall transformation from digitoxigenin also comprised the first conversion of a plant cardenolide to a plant bufadienolide (4).

Original language	English (US)
Pages (from-to)	2629-2631
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	39
Issue number	17
DOIs	https://doi.org/10.1021/jo00931a041
State	Published - Aug 1 1974

ASJC Scopus subject areas

Organic Chemistry

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abstract = "Bufalin (1), previously synthesized from digitoxigenin, was utilized as relay in a new synthetic route to scillarenin (4). Important steps in the synthesis of scillarenin included bromination and dehydrohalogenation of bufalone (2a) to yield scillarenone (3). The overall transformation from digitoxigenin also comprised the first conversion of a plant cardenolide to a plant bufadienolide (4).",

author = "Yoshiaki Kamano and George Pettit",

year = "1974",

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AU - Pettit, George

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AB - Bufalin (1), previously synthesized from digitoxigenin, was utilized as relay in a new synthetic route to scillarenin (4). Important steps in the synthesis of scillarenin included bromination and dehydrohalogenation of bufalone (2a) to yield scillarenone (3). The overall transformation from digitoxigenin also comprised the first conversion of a plant cardenolide to a plant bufadienolide (4).

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Bufadienolides. 26. Synthesis of Scillarenin

Abstract

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