Bufadienolides. 26. Synthesis of Scillarenin

Yoshiaki Kamano, George Pettit

Research output: Contribution to journalArticle

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Abstract

Bufalin (1), previously synthesized from digitoxigenin, was utilized as relay in a new synthetic route to scillarenin (4). Important steps in the synthesis of scillarenin included bromination and dehydrohalogenation of bufalone (2a) to yield scillarenone (3). The overall transformation from digitoxigenin also comprised the first conversion of a plant cardenolide to a plant bufadienolide (4).

Original languageEnglish (US)
Pages (from-to)2629-2631
Number of pages3
JournalJournal of Organic Chemistry
Volume39
Issue number17
DOIs
StatePublished - Aug 1 1974

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ASJC Scopus subject areas

  • Organic Chemistry

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