Bufalin (1), previously synthesized from digitoxigenin, was utilized as relay in a new synthetic route to scillarenin (4). Important steps in the synthesis of scillarenin included bromination and dehydrohalogenation of bufalone (2a) to yield scillarenone (3). The overall transformation from digitoxigenin also comprised the first conversion of a plant cardenolide to a plant bufadienolide (4).
ASJC Scopus subject areas
- Organic Chemistry