Bufadienolides. 11. Bufalin and resibufogenin

George Pettit, Leonard E. Houghton, John C. Knight, Fred Bruschweiler

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.

Original languageEnglish (US)
Pages (from-to)2895-2898
Number of pages4
JournalJournal of Organic Chemistry
Volume35
Issue number9
StatePublished - 1970

Fingerprint

Bufanolides
Digitoxigenin
Cardenolides
Acetates
bufalin
bufogenin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Pettit, G., Houghton, L. E., Knight, J. C., & Bruschweiler, F. (1970). Bufadienolides. 11. Bufalin and resibufogenin. Journal of Organic Chemistry, 35(9), 2895-2898.

Bufadienolides. 11. Bufalin and resibufogenin. / Pettit, George; Houghton, Leonard E.; Knight, John C.; Bruschweiler, Fred.

In: Journal of Organic Chemistry, Vol. 35, No. 9, 1970, p. 2895-2898.

Research output: Contribution to journalArticle

Pettit, G, Houghton, LE, Knight, JC & Bruschweiler, F 1970, 'Bufadienolides. 11. Bufalin and resibufogenin', Journal of Organic Chemistry, vol. 35, no. 9, pp. 2895-2898.
Pettit G, Houghton LE, Knight JC, Bruschweiler F. Bufadienolides. 11. Bufalin and resibufogenin. Journal of Organic Chemistry. 1970;35(9):2895-2898.
Pettit, George ; Houghton, Leonard E. ; Knight, John C. ; Bruschweiler, Fred. / Bufadienolides. 11. Bufalin and resibufogenin. In: Journal of Organic Chemistry. 1970 ; Vol. 35, No. 9. pp. 2895-2898.
@article{6dc98140637f4c5bb53a6007d5869196,
title = "Bufadienolides. 11. Bufalin and resibufogenin",
abstract = "A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.",
author = "George Pettit and Houghton, {Leonard E.} and Knight, {John C.} and Fred Bruschweiler",
year = "1970",
language = "English (US)",
volume = "35",
pages = "2895--2898",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Bufadienolides. 11. Bufalin and resibufogenin

AU - Pettit, George

AU - Houghton, Leonard E.

AU - Knight, John C.

AU - Bruschweiler, Fred

PY - 1970

Y1 - 1970

N2 - A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.

AB - A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.

UR - http://www.scopus.com/inward/record.url?scp=0014852896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014852896&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 2895

EP - 2898

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 9

ER -