Bufadienolides. 11. Bufalin and resibufogenin

George Pettit, Leonard E. Houghton, John C. Knight, Fred Bruschweiler

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34 Scopus citations


A total synthesis of resibufogenin (12b) and bufalin (1a) has been summarized. Digitoxigenin (2a) was employed as relay and converted to 14-dehydrobufalin acetate (11). The latter substance was transformed to resibufogenin (12b) and bufalin (1a). The synthesis represents a new approach to the bufadienolides and constitutes the first synthetic route from a cardenolide to a bufadienolide.

Original languageEnglish (US)
Pages (from-to)2895-2898
Number of pages4
JournalJournal of Organic Chemistry
Issue number9
StatePublished - Jan 1 1970

ASJC Scopus subject areas

  • Organic Chemistry

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    Pettit, G., Houghton, L. E., Knight, J. C., & Bruschweiler, F. (1970). Bufadienolides. 11. Bufalin and resibufogenin. Journal of Organic Chemistry, 35(9), 2895-2898. https://doi.org/10.1021/jo00834a008